protein

Lipocalin 2 / NGAL Immunizing Peptide

MBS425510

0.1 mg

190 USD

Blocking Peptide

Lipocalin 2 / NGAL Immunizing Peptide

[Lipocalin 2 / NGAL]

[Lcn2; lipocalin 2; NGAL; RP23-161B9.11; 24p3; AW212229; NGAL; Lipocalin 2; Lipocalin 2 / NGAL (mouse)]

[neutrophil gelatinase-associated lipocalin; Neutrophil gelatinase-associated lipocalin; neutrophil gelatinase-associated lipocalin; lipocalin 2; Lipocalin-2; SV-40-induced 24P3 protein; Siderocalin LCN2; p25]

[Lcn2]

[NGAL]

[Lcn2; Lcn2; 24p3; Sip24; AW212229; NGAL]

NGAL_MOUSE

200

C-HRYPQVQSYNVQ

100ug of Lyophilized peptide formulation 5pmol/ uL in 5% (v/v) acetonitrile /H2O. Reconstitute pellet in distilled water where required. For blocking studies, reconstitute pellet in 200 uL distilled water to obtain a 0.5 mg/mL petide solution.

Shipped at ambient temperature, store at -20°C

The peptide was used in the production of MBS425510 Goat Anti-Lipocalin 2/ngal (mouse) antibody. It is currently untested in blocking applications.

34328049

NP_032517.1

NM_008491.1

Iron Uptake And Transport Pathway (1368042); Transmembrane Transport Of Small Molecules Pathway (1368000)

LCN2: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Belongs to the calycin superfamily. Lipocalin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Cellular Component: cytosol; extracellular region; extracellular space. Molecular Function: iron ion binding; protease binding; protein binding; protein homodimerization activity; transporter activity. Biological Process: apoptosis; immune system process; innate immune response; ion transport; iron ion homeostasis; positive regulation of cell projection organization and biogenesis; response to drug; response to herbicide; response to virus; siderophore transport; transport

0.1 mg

190 USD