protein

ACACB Immunizing Peptide

MBS425499

0.1 mg

190 USD

Peptide

ACACB Immunizing Peptide

ACACB

ACACB; acetyl-Coenzyme A carboxylase beta; ACCB; HACC275; acetyl-CoA carboxylase 2

acetyl-Coenzyme A carboxylase beta; Acetyl-CoA carboxylase 2; acetyl-CoA carboxylase 2; acetyl-CoA carboxylase beta; ACC-betaIncluding the following 1 domains:Biotin carboxylase (EC:6.3.4.14)

ACACB

ACACB; ACACB; ACC2; ACCB; HACC275; ACC2; ACCB

ACACB_HUMAN

Human

2458

C-QLGEPDLSDKDRKD

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

61743950

NP_001084.2

NM_001093.2

255,093 Da

AMPK Signaling Pathway (198868); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Activation Of Gene Expression By SREBF (SREBP) Pathway (1270039); Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); BDNF Signaling Pathway (712093); Biotin Transport And Metabolism Pathway (1270153); ChREBP Activates Metabolic Gene Expression Pathway (1270114); Defective HLCS Causes Multiple Carboxylase Deficiency Pathway (1268975)

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008]

ACC2: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Activity is increased by oligomerization. Activated by citrate. Citrate and MID1IP1 promote oligomerization. Inhibited by malonyl-CoA. ACC1 is the predominant form expressed in liver, adipocyte and mammary gland. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC2 is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity. Two isoforms of the human protein are produced by alternative splicing. Protein type: EC 6.4.1.2; Carbohydrate Metabolism - pyruvate; Mitochondrial; Carbohydrate Metabolism - propanoate; Lipid Metabolism - fatty acid biosynthesis; EC 6.3.4.14; Ligase. Chromosomal Location of Human Ortholog: 12q24.11. Cellular Component: cytosol; endomembrane system; mitochondrial outer membrane; mitochondrion; nucleus. Molecular Function: acetyl-CoA carboxylase activity; ATP binding; biotin carboxylase activity; metal ion binding; protein binding. Biological Process: acetyl-CoA metabolic process; biotin metabolic process; carnitine shuttle; fatty acid biosynthetic process; negative regulation of catalytic activity; negative regulation of fatty acid beta-oxidation; positive regulation of cellular metabolic process; protein homotetramerization; response to nutrient levels

0.1 mg

190 USD