catalog number :
MBS425438
products full name :
AADACL1 Immunizing Peptide
products short name :
AADACL1
products name syn :
AADACL1; arylacetamide deacetylase-like 1
other names :
neutral cholesterol ester hydrolase 1 isoform b; Neutral cholesterol ester hydrolase 1; neutral cholesterol ester hydrolase 1; neutral cholesterol ester hydrolase 1; Arylacetamide deacetylase-like 1
products gene name :
AADACL1
other gene names :
NCEH1; NCEH1; NCEH; AADACL1; AADACL1; KIAA1363; NCEH
uniprot entry name :
NCEH1_HUMAN
reactivity :
Human, Mouse, Dog
sequence :
C-RTRNSYIKWLDQN
form :
100ug of dried peptide
storage stability :
Shipped at ambient temperature, store at -20 degree C
ncbi acc num :
NP_065843.3
ncbi gb acc num :
NM_020792.4
ncbi mol weight :
31,168 Da
ncbi pathways :
Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Lipid Digestion, Mobilization, And Transport Pathway (1270002); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001)
uniprot summary :
AADACL1: a single-pass type II membrane microsomal protein. Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (acetyl-glyceryl-ether-phosphorylcholine). Elevated in invasive cancer cells from several different tumor types. May be involved in the elevated neutral ether lipid content and elevated LPA signaling in cancer cells. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration. A key enzymatic node regulating an ether lipid signaling network in cancer; regulates MAGE and lysophospholipid levels in invasive cancer cells. Three alternatively spliced human isoforms have been described. Protein type: EC 3.1.1.-; Membrane protein, integral; Hydrolase. Chromosomal Location of Human Ortholog: 3q26.31. Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane. Molecular Function: sterol esterase activity. Biological Process: lipid catabolic process