protein

ITPR3 Immunizing Peptide

MBS425319

0.1 mg

190 USD

Blocking Peptide

ITPR3 Immunizing Peptide

[ITPR3]

[ITPR3; inositol 1,4,5-triphosphate receptor, type 3; HGNC: 6182; FLJ36205; IP3R; IP3R3]

[inositol 1,4,5-trisphosphate receptor type 3; Inositol 1,4,5-trisphosphate receptor type 3; inositol 1,4,5-trisphosphate receptor type 3; inositol 1,4,5-trisphosphate receptor type 3; IP3 receptor isoform 3; IP3R 3; InsP3R3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor]

[ITPR3]

[ITPR3; ITPR3; IP3R; IP3R3; IP3R 3; InsP3R3; Type 3 InsP3 receptor]

ITPR3_HUMAN

Human, Mouse, Rat, Dog, Cow

2671

C-DKKERPTDEEGFLH

100 ug of Lyophilized peptide formulation 5pmol/uL in 5% (v/v) acetonitrile/H2O. Reconstitute pellet in distilled water where required. For blocking studies, reconstitute pellet in 200 uL distilled water to obtain a 0.5 mg/mL peptide solution.

Shipped at ambient temperature, store at -20°C

The peptide was used in the production of MBS425319- Goat Anti-ITRP3 Antibody. It is currently untested in blocking applications.

153945846

NP_002215.2

NM_002224.3

Adaptive Immune System Pathway (1269171); Aldosterone Synthesis And Secretion Pathway (1272485); Aldosterone Synthesis And Secretion Pathway (1285075); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (1269184); Apoptosis Pathway (83060); Apoptosis Pathway (470); Beta-catenin Independent WNT Signaling Pathway (1269610)

This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]

IP3R3: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Expressed in intestinal crypt and villus epithelial cells. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues. Belongs to the InsP3 receptor family. Protein type: Membrane protein, integral; Channel, calcium; Channel, ligand-gated; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 6p21. Cellular Component: apical part of cell; brush border; cell soma; cytoplasm; cytosol; dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; integral to plasma membrane; membrane; myelin sheath; nuclear outer membrane; nucleolus; nucleoplasm; perinuclear region of cytoplasm; plasma membrane; receptor complex. Molecular Function: calcium ion binding; calcium-release channel activity; inositol 1,3,4,5 tetrakisphosphate binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity; inositol hexakisphosphate binding; phosphoinositide binding; protein binding. Biological Process: elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; inositol phosphate-mediated signaling; memory; platelet activation; protein heterooligomerization; protein homooligomerization; regulation of insulin secretion; release of sequestered calcium ion into cytosol; response to calcium ion; sensory perception of bitter taste; sensory perception of sweet taste; sensory perception of umami taste. Disease: Diabetes Mellitus, Insulin-dependent

0.1 mg

190 USD