Ghrelin preproprotein Immunizing Peptide | MyBioSource MBS425213 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Ghrelin preproprotein Immunizing Peptide

catalog :

MBS425213

quantity :

0.1 mg

price :

190 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS425213

products type :

Peptide

products full name :

Ghrelin preproprotein Immunizing Peptide

products short name :

Ghrelin preproprotein

products name syn :

GHRL; MTLRP; ghrelin; ghrelin precursor; motilin-related peptide; preproghrelin; ghrelin/obestatin prepropeptide; obestatin; OTTHUMP00000207794; OTTHUMP00000207795; OTTHUMP00000207796; OTTHUMP00000207798; ghrelin, growth hormone secretagogue receptor liga; Ghrelin preproprotein; Ghrelin preproprotein

other names :

appetite-regulating hormone isoform 1 preproprotein; Appetite-regulating hormone; appetite-regulating hormone; ghrelin/obestatin prepropeptide; Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide; Protein M46

products gene name :

GHRL

other gene names :

GHRL; GHRL; MTLRP; MTLRP; Ghrelin

uniprot entry name :

GHRL_HUMAN

reactivity :

Human

sequence length :

117

sequence :

C-QDILWEEAKEAPADK

form :

100ug of dried peptide

storage stability :

Shipped at ambient temperature, store at -20 degree C

ncbi gi num :

7706519

ncbi acc num :

NP_057446.1

ncbi gb acc num :

NM_016362.4

ncbi mol weight :

9,972 Da

ncbi pathways :

Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); G Alpha (q) Signalling Events Pathway (1269578); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); Gastrin-CREB Signalling Pathway Via PKC And MAPK (1269592); Metabolism Of Proteins Pathway (1268677); Peptide Hormone Metabolism Pathway (1268746); Peptide Ligand-binding Receptors Pathway (1269546); Signal Transduction Pathway (1269379); Signaling By GPCR Pathway (1269543)

ncbi summary :

This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression. [provided by RefSeq, Nov 2014]

uniprot summary :

ghrelin: a hormone that binds to the growth hormone secretagogue receptor type 1 (GHSR). Secreted by the stomach. Protein type: Cell cycle regulation; Secreted; Cell development/differentiation; Secreted, signal peptide; Apoptosis. Chromosomal Location of Human Ortholog: 3p26-p25. Cellular Component: axon; cytosol; endoplasmic reticulum lumen; extracellular region; extracellular space. Molecular Function: G-protein-coupled receptor binding; ghrelin receptor binding; growth hormone-releasing hormone activity; protein binding; protein tyrosine kinase activator activity. Biological Process: actin polymerization and/or depolymerization; activation of MAPK activity; adult feeding behavior; cartilage development; cortisol secretion; decidualization; dendrite development; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; gastric acid secretion; glucose metabolic process; growth hormone secretion; hormone-mediated signaling; negative regulation of angiogenesis; negative regulation of apoptosis; negative regulation of circadian sleep/wake cycle, REM sleep; negative regulation of endothelial cell proliferation; negative regulation of inflammatory response; negative regulation of insulin secretion; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 biosynthetic process; negative regulation of locomotion; negative regulation of tumor necrosis factor biosynthetic process; positive regulation of adrenocorticotropic hormone secretion; positive regulation of appetite; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of cortisol secretion; positive regulation of growth hormone secretion; positive regulation of insulin secretion; positive regulation of multicellular organism growth; positive regulation of synaptogenesis; regulation of cell proliferation; regulation of excitatory postsynaptic membrane potential; regulation of response to food; response to estrogen stimulus; response to hormone stimulus. Disease: Obesity

size1 :

0.1 mg

price1 :

190 USD

more info or order :

MyBioSource product webpage