protein

Insulysin / Insulinase Immunizing Peptide

MBS425175

0.1 mg

190 USD

Peptide

Insulysin / Insulinase Immunizing Peptide

Insulysin / Insulinase

insulinase; insulysin; insulin-degrading enzyme; FLJ35968; INSULYSIN; Insulysin; Insulinase; Insulysin / Insulinase

insulysin; Insulin-degrading enzyme; insulin-degrading enzyme; insulin degrading enzyme; Abeta-degrading protease; Insulin protease; Insulinase; Insulysin

IDE

IDE; IDE; INSULYSIN; Insulinase

IDE_HUMAN

Human, Dog

1019

C-QQYNFDRDNTE

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

4826770

NP_004960.1,

NM_004969.1

54,240 Da

Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448)

This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]

IDE: Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. Belongs to the peptidase M16 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Nuclear receptor co-regulator; Cell surface; EC 3.4.24.56; Protease. Chromosomal Location of Human Ortholog: 10q23-q25. Cellular Component: cell surface; cytoplasm; cytosol; extracellular space; mitochondrion; nucleoplasm; nucleus; peroxisomal matrix; peroxisome; plasma membrane. Molecular Function: ATP binding; ATPase activity; beta-amyloid binding; beta-endorphin binding; glycoprotein binding; insulin binding; metalloendopeptidase activity; peptide binding; protein binding; protein homodimerization activity; receptor binding; ubiquitin binding; viral receptor activity; zinc ion binding. Biological Process: beta-amyloid metabolic process; determination of adult life span; entry of virus into host cell; hormone catabolic process; insulin receptor signaling pathway; negative regulation of proteolysis; positive regulation of protein oligomerization; protein heterooligomerization; protein homooligomerization; protein homotetramerization; protein processing; proteolysis; proteolysis involved in cellular protein catabolic process

0.1 mg

190 USD