protein

ABCE1 / RNase L Immunizing Peptide

MBS425125

0.1 mg

190 USD

Peptide

ABCE1 / RNase L Immunizing Peptide

ABCE1 / RNase L

ABCE1; ATP-binding cassette, sub-family E (OABP), member 1; ABC38; OABP; RLI; RNASEL1; RNASELI; RNS4I; ATP-binding cassette, sub-family E, member 1; RNase L inhibitor; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor; ABCE1 / RNase L

ATP-binding cassette sub-family E member 1; ATP-binding cassette sub-family E member 1; ATP-binding cassette sub-family E member 1; ATP binding cassette subfamily E member 1; 2'-5'-oligoadenylate-binding protein; HuHP68; RNase L inhibitor; Ribonuclease 4 inhibitor; RNS4I

ABCE1

RNase L

ABCE1; ABCE1; RLI; OABP; ABC38; RNS4I; RNASEL1; RNASELI; RLI; RNASEL1; RNASELI; RNS4I; RNS4I

ABCE1_HUMAN

Human, Mouse, Rat, Dog, Cow

599

NHDKCKPKKCRQEC

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

108773782

NP_002931.2

NM_002940.2

67,314 Da

ABC-family Proteins Mediated Transport Pathway (1269904); Transmembrane Transport Of Small Molecules Pathway (1269903)

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

ABCE1: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. Belongs to the ABC transporter superfamily. ABCE family. Chromosomal Location of Human Ortholog: 4q31. Cellular Component: cytoplasm; membrane; mitochondrial matrix; mitochondrion. Molecular Function: ATP binding; ATPase activity; protein binding; ribonuclease inhibitor activity. Biological Process: negative regulation of catalytic activity; response to virus; RNA catabolic process; transmembrane transport; viral reproduction

0.1 mg

190 USD