protein

COL4A6 Immunizing Peptide

MBS425045

0.1 mg

190 USD

Peptide

COL4A6 Immunizing Peptide

COL4A6

COL4A6; collagen, type IV, alpha 6; MGC88184; OTTHUMP00000023834; OTTHUMP00000023835; collagen IV, alpha-6 polypeptide; collagen alpha 6 type IV; collagen of basement membrane, alpha-6; dJ889N15.4 (Collagen Alpha 6(IV)); type IV alpha 6 collagen

collagen alpha-6(IV) chain isoform A; Collagen alpha-6(IV) chain; collagen alpha-6(IV) chain; collagen type IV alpha 6

COL4A6

COL4A6; COL4A6; DFNX6; DELXq22.3; CXDELq22.3

CO4A6_HUMAN

Human

1691

C-PSPEFETETLHNKES

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

148536823

NP_001838.2

NM_001847.3

163,629 Da

AGE-RAGE Signaling Pathway In Diabetic Complications (1319988); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (1270247); Collagen Biosynthesis And Modifying Enzymes Pathway (1270246); Collagen Formation Pathway (1270245); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (1270244)

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]

COL4A6: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Deletions covering the N-terminal regions of COL4A5 and COL4A6, which are localized in a head-to-head manner, are found in the chromosome Xq22.3 centromeric deletion syndrome. This results in a phenotype with features of diffuse leiomyomatosis and Alport syndrome (DL-ATS). Belongs to the type IV collagen family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Extracellular matrix; Secreted. Chromosomal Location of Human Ortholog: Xq22. Cellular Component: collagen type IV; endoplasmic reticulum lumen; extracellular region. Molecular Function: extracellular matrix structural constituent. Biological Process: cell adhesion; collagen catabolic process; extracellular matrix organization and biogenesis. Disease: Deafness, X-linked 6

0.1 mg

190 USD