catalog number :
MBS425013
products full name :
Cytochrome b reductase 1 Immunizing Peptide
products short name :
Cytochrome b reductase 1
products name syn :
CYBRD1; DCYTB; FLJ23462; cytochrome b reductase 1; duodenal cytochrome b; FRRS3; ferric-chelate reductase 3; Cytochrome b reductase 1; Cytochrome b reductase 1
other names :
cytochrome b reductase 1 isoform 1; Cytochrome b reductase 1; cytochrome b reductase 1; cytochrome b reductase 1; Duodenal cytochrome b; Ferric-chelate reductase 3
products gene name :
CYBRD1
other gene names :
CYBRD1; CYBRD1; DCYTB; FRRS3; CYB561A2; DCYTB; FRRS3
uniprot entry name :
CYBR1_HUMAN
reactivity :
Human, Dog, Pig, Cow
sequence :
CRNLALDEAGQRSTM
form :
100ug of dried peptide
storage stability :
Shipped at ambient temperature, store at -20 degree C
ncbi acc num :
NP_079119.3
ncbi gb acc num :
NM_024843.3
ncbi mol weight :
25,087 Da
ncbi pathways :
Iron Uptake And Transport Pathway (1269948); Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); Transmembrane Transport Of Small Molecules Pathway (1269903)
ncbi summary :
This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 2008]
uniprot summary :
CYBRD1: Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel; Oxidoreductase; Transporter, iron; Motility/polarity/chemotaxis; Transporter; EC 1.-.-.-. Chromosomal Location of Human Ortholog: 2q31.1. Cellular Component: brush border membrane; integral to membrane; plasma membrane. Molecular Function: ferric-chelate reductase activity; metal ion binding; oxidoreductase activity, oxidizing metal ions; protein binding. Biological Process: cellular iron ion homeostasis; response to iron ion