catalog number :
MBS423308
products full name :
Goat anti-DMRT2 Antibody
products short name :
[DMRT2]
products name syn :
[DMRT2; doublesex and mab-3 related transcription factor 2; OTTHUMP00000020964; OTTHUMP00000020965; OTTHUMP00000020966; OTTHUMP00000020967; terra-like protein; DMRT2 antibody; doublesex and mab-3 related transcription factor 2 antibody; OTTHUMP00000020964 antibody; OTTHUMP00000020965 antibody; OTTHUMP00000020966 antibody; OTTHUMP00000020967 antibody; terra-like protein antibody]
other names :
[doublesex- and mab-3-related transcription factor 2 isoform 1; Doublesex- and mab-3-related transcription factor 2; doublesex- and mab-3-related transcription factor 2; doublesex and mab-3 related transcription factor 2; Doublesex-like 2 protein; DSXL-2]
products gene name :
[DMRT2]
other gene names :
[DMRT2; DMRT2; DSXL2; DSXL-2]
uniprot entry name :
DMRT2_HUMAN
reactivity :
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
storage stability :
Aliquot and store at -20°C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Immunohistochemistry (IHC)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 8000. IHC: In paraffin embedded Human Kidney shows nuclear staining primarily in the DCT. Recommended concentration, 2-4ug/ml.
image1 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Peptide with sequence C-KRPSSAITRVSQ, from the C Terminus of the protein sequence according to NP_006548.1; NP_870987.2
other info2 :
Note: This antibody is expected to recognize isoform 2 only (NP_870987.2). Reported variants NP_001124337.1 and NP_006548.1 represent identical protein
ncbi acc num :
NP_006548.1
ncbi gb acc num :
NM_006557.6
ncbi summary :
The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. [provided by RefSeq, Apr 2010]
uniprot summary :
DMRT2: belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. [provided by RefSeq, Apr 2010]. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 9p24.3. Cellular Component: nucleus. Molecular Function: metal ion binding; protein homodimerization activity; transcription factor activity. Biological Process: embryonic skeletal development; positive regulation of transcription from RNA polymerase II promoter; regulation of somitogenesis; sex differentiation; transcription, DNA-dependent