catalog number :
MBS423149
products full name :
Goat anti-Antigen KI-67/MKI67 (aa98-110) Antibody
products short name :
[Antigen KI-67/MKI67]
products name syn :
[Goat Anti-Ki-67 / MKI67 Antibody; MKI67; antigen identified by monoclonal antibody Ki-67; KIA; OTTHUMP00000020739; OTTHUMP00000020740; antigen KI-67; proliferation-related Ki-67 antigen; antigen identified by monoclonal antibody Ki-67 antibody; antigen KI-67 antibody; KIA antibody; MKI67 antibody; OTTHUMP00000020739 antibody; OTTHUMP00000020740 antibody; proliferation-related Ki-67 antigen antibody; Antigen KI-67; Antigen KI-67 / MKI67 (aa98-110)]
other names :
[antigen KI-67 isoform 1; Antigen KI-67; antigen KI-67; marker of proliferation Ki-67]
products gene name :
[MKI67]
other gene names :
[MKI67; MKI67; KIA; MIB-; MIB-1; PPP1R105]
uniprot entry name :
KI67_HUMAN
reactivity :
Expected from sequence similarity: Human
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Not yet tested - our routinely used western blotting protocol does not allow detection of proteins >250kDa. Therefore we cannot recommend an optimal concentration, and the antibody is an aspiring product.
other info1 :
Immunogen: Peptide with sequence ENESLQNGRKSTE-C, from the N Terminus of the protein sequence according to NP_002408.3; NP_001139438.1.
other info2 :
Note: This antibody is expected to recognize both reported isoforms (NP_002408.3; NP_001139438.1). Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-7846
ncbi acc num :
NP_002408.3
ncbi gb acc num :
NM_002417.4
ncbi summary :
This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]
uniprot summary :
KI-67: a protein that may be a marker of proliferating cells, involved in chromatin compaction. Its expression is altered in many tumor types including osteosarcomas, histiocytomas, prostate, breast and esophageal cancers. Mutated in colon, cervical and lung cancers. Protein type: Cell cycle regulation; Nucleolus. Chromosomal Location of Human Ortholog: 10q26.2. Cellular Component: condensed chromosome; membrane; nucleolus; nucleus. Molecular Function: protein binding; protein C-terminus binding. Biological Process: cell proliferation; regulation of chromosome segregation; regulation of mitosis