catalog number :
MBS423117
products full name :
Goat anti-KLF2/LKLF Antibody
products short name :
KLF2/LKLF
products name syn :
KLF2; Kruppel-like factor 2 (lung); LKLF; Kruppel-like factor LKLF; lung Kruppel-like zinc finger transcription factor; KLF2 antibody; Kruppel-like factor 2 (lung) antibody; LKLF antibody; Kruppel-like factor LKLF antibody; lung Kruppel-like zinc finger transcription factor antibody; KLF2 / LKLF
other names :
Krueppel-like factor 2; Krueppel-like factor 2; Krueppel-like factor 2; Kruppel-like factor 2; Lung krueppel-like factor
products gene name :
KLF2
products gene name syn :
LKLF
other gene names :
KLF2; KLF2; LKLF; LKLF
uniprot entry name :
KLF2_HUMAN
reactivity :
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 37kDa band observed in Human Heart and Lung lysates (calculated MW of 37.4kDa according to NP_057354.1). Recommended concentration: 1-3ug/ml.
other info1 :
Immunogen: Peptide with sequence ALSEPILPSFST-C, from the N Terminus of the protein sequence according to NP_057354.1. Epitope: N Terminus
ncbi acc num :
NP_057354.1
ncbi gb acc num :
NM_016270.3
ncbi mol weight :
37,420 Da
ncbi pathways :
FoxO Signaling Pathway (921162)
ncbi summary :
Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 [PubMed 19592277]).[supplied by OMIM, Feb 2011]
uniprot summary :
KLF2: Binds to the CACCC box in the beta-globin gene promoter and activates transcription. Belongs to the krueppel C2H2-type zinc-finger protein family. Protein type: C2H2-type zinc finger protein; DNA-binding. Chromosomal Location of Human Ortholog: 19p13.11. Cellular Component: nucleus. Molecular Function: metal ion binding; protein binding; sequence-specific DNA binding; transcription factor activity. Biological Process: cell morphogenesis; erythrocyte maturation; in utero embryonic development; multicellular organism growth; negative regulation of interleukin-6 production; positive regulation of nitric oxide biosynthetic process; positive regulation of protein metabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of gene expression, epigenetic; transcription, DNA-dependent