Goat anti-TNF-R-II/TNFR2 (mouse) Antibody | MyBioSource MBS422890 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-TNF-R-II/TNFR2 (mouse) Antibody

catalog :

MBS422890

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS422890

products type :

Antibody

products full name :

Goat anti-TNF-R-II/TNFR2 (mouse) Antibody

products short name :

TNF-R-II/TNFR2

products name syn :

Tnfrsf1b; tumor necrosis factor receptor superfamily, member 1B; CD120b; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80; p75; p75TNFR; TNF-R2; TNF-RII; TNFR-II; p75 TNF receptor; p80 TNF-alpha receptor; soluble TNFR1B variant 1; tumor necrosis fac; CD120b antibody; p75 antibody; p75 TNF receptor antibody; p75TNFR antibody; p80 TNF-alpha receptor antibody; soluble TNFR1B variant 1 antibody; TBPII antibody; TNFBR antibody; TNFR1B antibody; TNFR2 antibody; TNF-R2 antibody; TNF-R75 antibody; TNFR80 antibody; TNFR-II antibody; TNF-RII antibody; TNF-R-II antibody; tumor necrosis factor beta receptor antibody; tumor necrosis factor binding protein 2 antibody; tumor necrosis factor receptor 2 antibody; tumor necrosis factor receptor superfamily member 1B antibody; tumor necrosis factor receptor superfamily; member 1B antibody; tumor necrosis factor receptor type II antibody; Tnfrsf1b antibody; TNF-R-II / TNFR2 (mouse)

other names :

tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily, member 1b; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD_antigen: CD120b

products gene name :

Tnfrsf1b

products gene name syn :

TNF-R-II; TNFR2

other gene names :

Tnfrsf1b; Tnfrsf1b; p75; TNFBR; Tnfr2; CD120b; TNF-R2; TNFR80; TNFRII; Tnfr-1; TNF-R75; TNF-R-II; TNF-alphaR2; TNFalpha-R2; Tnfr-2; Tnfr2; TNF-R2; TNF-RII; TNFR-II

uniprot entry name :

TNR1B_MOUSE

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Mouse, Rat; Expected from sequence similarity: Mouse, Rat

sequence length :

474

sequence :

KHFCNKTSDTVCAD

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Approx 55kDa band observed in Mouse and Rat Spinal Cord lysates (calculated MW of 50.3kDa according to Mouse NP_035740.2). Recommended concentration: 0.2-0.6ug/ml.

other info1 :

Immunogen: Peptide with sequence KHFCNKTSDTVCAD, from the internal region of the protein sequence according to NP_035740.2. Epitope: Internal region

other info2 :

Note: The immunizing peptide represents part of a potential extracellular domain.

ncbi gi num :

70778792

ncbi acc num :

NP_035740.2

ncbi gb acc num :

NM_011610.3

ncbi mol weight :

50,320 Da

ncbi pathways :

Adipocytokine Signaling Pathway (83290); Adipocytokine Signaling Pathway (505); Amyotrophic Lateral Sclerosis (ALS) Pathway (83296); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Apoptosis Pathway (198339); Cytokine Signaling In Immune System Pathway (1367586); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); IL-3 Signaling Pathway (198420); Immune System Pathway (1367472)

uniprot summary :

TNF-R2: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Binds to TRAF2. Interacts with BMX. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, cytokine. Cellular Component: axon; cell soma; integral to membrane; integral to plasma membrane; lipid raft; membrane; nucleus; perinuclear region of cytoplasm. Molecular Function: protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding. Biological Process: cell proliferation; cell surface receptor linked signal transduction; DNA damage response, signal transduction resulting in induction of apoptosis; immune response; inflammatory response; multicellular organismal development; negative regulation of inflammatory response; positive regulation of MAPKKK cascade; positive regulation of membrane protein ectodomain proteolysis; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide; RNA destabilization

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage