catalog number :
MBS422828
products full name :
Goat anti-NDR1/STK38 Antibody
products short name :
NDR1/STK38
products name syn :
Goat Anti-NDR1 / STK38 (aa362-377) Antibody; STK38; serine/threonine kinase 38; NDR; NDR1; NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related 1; nuclear Dbf2-related kinase 1; serine threonine protein kinase; serine/threonine-protein kinase 38; STK38 antibody; serine/threonine kinase 38 antibody; NDR antibody; NDR1 antibody; NDR1 protein kinase antibody; Ndr Ser/Thr kinase-like protein antibody; nuclear Dbf2-related 1 antibody; nuclear Dbf2-related kinase 1 antibody; serine threonine protein kinase antibody; NDR1 / STK38
other names :
serine/threonine-protein kinase 38; Serine/threonine-protein kinase 38; serine/threonine-protein kinase 38; serine/threonine kinase 38; NDR1 protein kinase; Nuclear Dbf2-related kinase 1
products gene name :
STK38
products gene name syn :
NDR1
other gene names :
STK38; STK38; NDR; NDR1
uniprot entry name :
STK38_HUMAN
reactivity :
Tested: Human, Rat; Expected from sequence similarity: Human, Rat, Dog, Pig, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 55kDa band observed in Human and Rat Spleen lysates (calculated MW of 54.2kDa according to NP_009202.1). Recommended concentration: 0.5-2ug/ml.
other info1 :
Immunogen: Peptide with sequence C-KPTVATSNHPET, from the C Terminus (near) of the protein sequence according to NP_009202.1. Epitope: C Terminus (near)
other info2 :
Note: This antibody is NOT expected to cross-react with STK38L (GeneID 23012).
ncbi acc num :
NP_009202.1
ncbi gb acc num :
NM_007271.3
ncbi mol weight :
54,190 Da
ncbi summary :
This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
uniprot summary :
NDR1: is an AGC kinase of the NDR family. An apparent upstream regulator of Myc activity in human B-cell lymphoma. Mediates apoptosis downstream of the tumor suppressor proteins RASSF1A and MST1. Reduced expression of NDR1 results in defective apoptotic responses and a predisposition to develop T cell lymphoma in mice. Activated by binding of S100B which releases autoinhibitory N-lobe interactions. Ubiquitously expressed with highest levels observed in peripheral blood leukocytes. Protein type: Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; AGC group; NDR family. Chromosomal Location of Human Ortholog: 6p21. Cellular Component: cytoplasm; nucleus. Molecular Function: ATP binding; magnesium ion binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein serine/threonine kinase activity. Biological Process: negative regulation of MAP kinase activity; peptidyl-serine phosphorylation; protein amino acid phosphorylation; protein modification process