antibody

Goat anti-MNSOD (aa119-130) Antibody

MBS422763

0.1 mg

300 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog, zebrafish

western blot, enzyme immunoassay

Antibody

Goat anti-MNSOD (aa119-130) Antibody

MNSOD

Goat Anti-MNSOD (isoform A) Antibody; SOD2; superoxide dismutase 2, mitochondrial; RP1-56L9.2; IPOB; MNSOD; MVCD6; Mn superoxide dismutase; indophenoloxidase B; manganese-containing superoxide dismutase; mangano-superoxide dismutase; superoxide dismutase [Mn], mitochondrial; SOD2 antibody; superoxide dismutase 2; mitochondrial antibody; RP1-56L9.2 antibody; IPOB antibody; MNSOD antibody; MVCD6 antibody; Mn superoxide dismutase antibody; indophenoloxidase B antibody; manganese-containing superoxide dismutase antibody; superoxide dismutase [Mn]; mitochondrial antibody; MNSOD (aa119-130)

superoxide dismutase; Superoxide dismutase [Mn], mitochondrial; superoxide dismutase [Mn], mitochondrial; superoxide dismutase 2, mitochondrial

SOD2

MNSOD

SOD2; SOD2; IPOB; IPO-B; MNSOD; MVCD6; Mn-SOD

SODM_HUMAN

Polyclonal

Goat

Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow, Zebrafish

222

EAIKRDFGSFDK

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: Approx 24kDa band observed in Human Brain (cerebellum) lysates and in Mouse and Rat Brain and Spinal Cord lysates, while approx 26kDa band was observed in lysates of cell lines HeLa, HepG2, HEK293 and NIH3T3 (calculated MW of 24.8kDa according to Human NP_000627.2, and 24.6kDa according to Mouse NP_038699.2). Recommended concentration: 0. 01-0.1ug/ml.

Immunogen: Peptide with sequence C-EAIKRDFGSFDK, from the internal region of the protein sequence according to NP_000627.2; NP_001019637.1. Epitope: Internal region

Note: NB: The immunizing peptide represents the acetylation site including K122 according to isoform A. This antibody is expected to recognize both reported isoforms (NP_000627.2; NP_001019637.1). Reported variants represent identical protein: NP_000627.2; NP_001019636.1.

67782305

NP_000627.2

NM_000636.3

19,730 Da

Cellular Responses To Stress Pathway (1270414); DNA Damage Response (only ATM Dependent) Pathway (198827); Detoxification Of Reactive Oxygen Species Pathway (1270420); FoxO Family Signaling Pathway (138036); FoxO Signaling Pathway (921162); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Longevity Regulating Pathway (1319989); Longevity Regulating Pathway - Multiple Species (1340713); Longevity Regulating Pathway - Multiple Species (1340651)

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]

SOD2: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the iron/manganese superoxide dismutase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Oxidoreductase; EC 1.15.1.1; Mitochondrial. Chromosomal Location of Human Ortholog: 6q25.3. Cellular Component: mitochondrial matrix; mitochondrion. Molecular Function: identical protein binding; manganese ion binding; superoxide dismutase activity. Biological Process: acetylcholine vasodilation involved in regulation of systemic arterial blood pressure; age-dependent response to reactive oxygen species; negative regulation of cell proliferation; negative regulation of neuron apoptosis; oxygen homeostasis; protein homotetramerization; regulation of blood pressure; regulation of transcription from RNA polymerase II promoter; release of cytochrome c from mitochondria; removal of superoxide radicals; response to reactive oxygen species; response to superoxide; superoxide metabolic process. Disease: Microvascular Complications Of Diabetes, Susceptibility To, 6

0.1 mg

300 USD