antibody

Goat anti-TERT (aa597-611) Antibody

MBS422741

0.1 mg

300 USD

polyclonal

goat

nonconjugated

western blot, enzyme immunoassay

Antibody

Goat anti-TERT (aa597-611) Antibody

TERT

TERT; telomerase reverse transcriptase; EST2; TCS1; TP2; TRT; hEST2; telomerase catalytic subunit; telomerase-associated protein 2; EST2 antibody; hEST2 antibody; TCS1 antibody; telomerase catalytic subunit antibody; telomerase reverse transcriptase antibody; telomerase-associated protein 2 antibody; TP2 antibody; TRT antibody; TERT antibody; TERT (aa597-611)

telomerase reverse transcriptase isoform 1; Telomerase reverse transcriptase; telomerase reverse transcriptase; telomerase reverse transcriptase; HEST2; Telomerase catalytic subunit; Telomerase-associated protein 2; TP2

TERT

TERT; TERT; TP2; TRT; CMM9; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1; EST2; TCS1; TRT; TP2

TERT_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human

1132

QLRELSEAEVRQHRE

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 140kDa band observed in Human Heart and Skeletal Muscle lysates (calculated MW of 127kDa according to NP_937983.2). Recommended concentration: 0.3-1ug/ml.

Immunogen: Peptide with sequence C-QLRELSEAEVRQHRE, from the internal region of the protein sequence according to NP_937983.2; NP_001180305.1. Epitope: Internal region

Note: This antibody is expected to recognize both reported isoforms (NP_937983.2; (NP_001180305.1).

109633031

NP_937983.2

NM_198253.2

88,965 Da

Cell Cycle Pathway (1269741); Chromosome Maintenance Pathway (1269853); Extension Of Telomeres Pathway (1269857); Formation Of The Beta-catenin:TCF Transactivating Complex Pathway (1269602); HIF-1-alpha Transcription Factor Network Pathway (138045); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); IL2 Signaling Events Mediated By PI3K Pathway (137938); Id Signaling Pathway (198871); Regulation Of Telomerase Pathway (137987)

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]

TERT: telomerase reverse transcriptase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The holoenzyme consists of TERT and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced isoforms have been identified, although the full-length sequence of some variants has not been determined. Protein type: Nucleolus; DNA-binding; EC 2.7.7.49; Transferase. Chromosomal Location of Human Ortholog: 5p15.33. Cellular Component: chromosome, telomeric region; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleolus; nucleoplasm; nucleus; PML body; telomerase holoenzyme complex. Molecular Function: DNA binding; metal ion binding; nucleotidyltransferase activity; protein binding; protein homodimerization activity; RNA binding; RNA-directed DNA polymerase activity; RNA-directed RNA polymerase activity; telomerase activity; telomeric DNA binding; telomeric template RNA reverse transcriptase activity; tRNA binding. Biological Process: DNA strand elongation; mitochondrion organization and biogenesis; positive regulation of hair cycle; positive regulation of nitric-oxide synthase activity; positive regulation of protein binding; positive regulation of Wnt receptor signaling pathway; regulation of protein stability; RNA biosynthetic process; RNA interference, production of siRNA; RNA-dependent DNA replication; telomere maintenance; telomere maintenance via telomerase. Disease: Aplastic Anemia; Dyskeratosis Congenita, Autosomal Dominant, 1; Pulmonary Fibrosis, Idiopathic

0.1 mg

300 USD