Goat anti-Fgf23 (mouse) Antibody | MyBioSource MBS422726 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Fgf23 (mouse) Antibody

catalog :

MBS422726

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS422726

products type :

Antibody

products full name :

Goat anti-Fgf23 (mouse) Antibody

products short name :

Fgf23

products name syn :

Fgf23; fibroblast growth factor 23; ADHR; HPDR2; HYPF; PHPTC; FGF-23; phosphatonin; tumor-derived hypophosphatemia inducing factor; tumor-derived hypophosphatemia-inducing factor; ADHR antibody; FGF-23 antibody; fibroblast growth factor 23 antibody; HPDR2 antibody; HYPF antibody; phosphatonin antibody; PHPTC antibody; tumor-derived hypophosphatemia inducing factor antibody; tumor-derived hypophosphatemia-inducing factor antibody; Fgf23 antibody; Fgf23 (mouse)

other names :

fibroblast growth factor 23; Fibroblast growth factor 23; fibroblast growth factor 23; fibroblast growth factor 23

products gene name :

Fgf23

other gene names :

Fgf23; Fgf23; FGF-23

uniprot entry name :

FGF23_MOUSE

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Mouse; Expected from sequence similarity: Mouse, Rat

sequence length :

251

sequence :

ENGYDVYLSQKHH

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 27+38kDa bands observed in Mouse Brain lysates (calculated MW of 27.7kDa according to NP_073148.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Garringer et al, Am J Physiol Endocrinol Metab.2008 Oct;295(4): E929-37. PMID: 18682534). Recommended concentration: 0.5-2ug/ml.

other info1 :

Immunogen: Peptide with sequence C-ENGYDVYLSQKHH, from the internal region of the protein sequence according to NP_073148.1. Epitope: Internal region

ncbi gi num :

12083589

ncbi acc num :

NP_073148.1

ncbi gb acc num :

NM_022657.4

ncbi mol weight :

27,758 Da

ncbi pathways :

ARMS-mediated Activation Pathway (1366978); Adaptive Immune System Pathway (1367473); Axon Guidance Pathway (1366709); Cytokine Signaling In Immune System Pathway (1367586); DAP12 Interactions Pathway (1367572); DAP12 Signaling Pathway (1367573); Developmental Biology Pathway (1366708); Downstream Signal Transduction Pathway (1366988); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (1367487); Downstream Signaling Of Activated FGFR1 Pathway (1366902)

ncbi summary :

This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function. [provided by RefSeq, Mar 2013]

uniprot summary :

FGF23: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR). ADHR is characterized by low serum phosphorus concentrations, rickets, osteomalacia, leg deformities, short stature, bone pain and dental abscesses. Defects in FGF23 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC). HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Belongs to the heparin-binding growth factors family. Protein type: Secreted, signal peptide; Cytokine; Secreted. Cellular Component: extracellular region; extracellular space. Molecular Function: fibroblast growth factor receptor binding; growth factor activity; protein binding; type 1 fibroblast growth factor receptor binding. Biological Process: cell differentiation; cellular phosphate ion homeostasis; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; negative regulation of bone mineralization; negative regulation of hormone secretion; negative regulation of osteoblast differentiation; phosphate ion homeostasis; positive regulation of transcription, DNA-dependent; regulation of bone mineralization; vitamin D catabolic process

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage