catalog number :
MBS422719
products full name :
Goat anti-ANGPT1 Antibody
products short name :
ANGPT1
products name syn :
AGP1; AGPT; ANG1; angiopoietin 1; ANGPT1; angiopoietin 1; AGP1; AGPT; ANG1
other names :
angiopoietin-1 isoform 1; Angiopoietin-1; angiopoietin-1; ANG-1; angiopoietin 1
products gene name :
ANGPT1
other gene names :
ANGPT1; ANGPT1; AGP1; AGPT; ANG1; KIAA0003; ANG-1
uniprot entry name :
ANGP1_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Cow, Pig
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB-Trf)
app notes :
Western Blot: In transfected HEK293 transiently expressing full-length Human ANGPT1 (myc and DYKDDDDK tagged), a band of approx. 48kDa was observed. No bands were observed in mock-transfected HEK293 and the 48kDa plus a 75kDa band was observed using anti-DYKDDDDK tag antibody. Recommended concentration, 1-2ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-PDFSSQKLQH, from the internal region of the protein sequence according to NP_001137.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS427424
ncbi acc num :
NP_001137.2
ncbi gb acc num :
NM_001146.3
ncbi mol weight :
57,456 Da
ncbi pathways :
Angiogenesis Pathway 198772!!Angiopoietin Receptor Tie2-mediated Signaling Pathway 137917!!Cell Surface Interactions At The Vascular Wall Pathway 106062!!HIF-1 Signaling Pathway 695200!!Hemostasis Pathway 106028!!PI3K-Akt Signaling Pathway 692234!!PI3K-Akt Signaling Pathway 692979!!Rap1 Signaling Pathway 868086!!Rap1 Signaling Pathway 878042!!Ras Signaling Pathway 868085
ncbi summary :
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]