catalog number :
MBS422666
products full name :
Goat anti-PAPD5 (aa78-90) Antibody
products short name :
PAPD5
products name syn :
Goat Anti-TRF4-2 / PAPD5 Antibody; PAPD5; PAP associated domain containing 5; FLJ40270; TRF4-2; PAP-associated domain-containing protein 5; TUTase 3; terminal uridylyltransferase 3; topoisomerase-related function protein 4-2; PAPD5 antibody; PAP associated domain containing 5 antibody; FLJ40270 antibody; TRF4-2 antibody; PAP-associated domain-containing protein 5 antibody; TUTase 3 antibody; terminal uridylyltransferase 3 antibody; topoisomerase-related function protein 4-2 antibody; PAPD5 (aa78-90)
other names :
non-canonical poly(A) RNA polymerase PAPD5 isoform a; Non-canonical poly(A) RNA polymerase PAPD5; non-canonical poly(A) RNA polymerase PAPD5; PAP associated domain containing 5; PAP-associated domain-containing protein 5; Terminal uridylyltransferase 3; TUTase 3; Topoisomerase-related function protein 4-2; TRF4-2
products gene name :
PAPD5
other gene names :
PAPD5; PAPD5; TRF4-2; TUTase 3; TRF4-2
uniprot entry name :
PAPD5_HUMAN
reactivity :
Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: Approx 75-80kDa band observed in Human and Mouse Brain lysates (calculated MW of 75.8kDa according to Human NP_001035374.2 and 74.2kDa according to Mouse NP_001157969.1). Recommended concentration: 0.3-1ug/ml.
other info1 :
Immunogen: Peptide with sequence C-HALPAEQRDFLP, from the internal region of the protein sequence according to NP_001035374.2; NP_001035375.2. Epitope: Internal region
other info2 :
Note: This antibody is expected to recognize both reported isoforms (NP_001035374.2; NP_001035375.2).
ncbi acc num :
NP_001035374.2
ncbi gb acc num :
NM_001040284.2
ncbi mol weight :
75,801 Da
ncbi pathways :
RNA Degradation Pathway (117291); RNA Degradation Pathway (116127); TRAMP Complex Pathway (413459); TRAMP Complex Pathway (468399)
uniprot summary :
PAPD5: Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion. Belongs to the DNA polymerase type-B-like family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: EC 2.7.7.19; Transferase; Nucleolus. Chromosomal Location of Human Ortholog: 16q12.1. Cellular Component: cytoplasm; nucleolus. Molecular Function: DNA binding; DNA-directed DNA polymerase activity; metal ion binding; polynucleotide adenylyltransferase activity. Biological Process: cell division; mitosis; mRNA processing; rRNA processing