Goat anti-AMPA1/GLUR1 (aa264-277) Antibody | MyBioSource MBS422615 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-AMPA1/GLUR1 (aa264-277) Antibody

catalog :

MBS422615

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS422615

products type :

Antibody

products full name :

Goat anti-AMPA1/GLUR1 (aa264-277) Antibody

products short name :

AMPA1/GLUR1

products name syn :

Goat Anti-AMPA1 / GLUR1 Antibody; GRIA1; glutamate receptor, ionotropic, AMPA 1; GLUH1; GLUR1; GLURA; GluA1; HBGR1; MGC133252; AMPA 1; AMPA-selective glutamate receptor 1; gluR-1; gluR-A; gluR-K1; glutamate receptor 1; GRIA1 antibody; glutamate receptor; ionotropic; AMPA 1 antibody; GLUH1 antibody; GLUR1 antibody; GLURA antibody; GluA1 antibody; HBGR1 antibody; MGC133252 antibody; AMPA 1 antibody; gluR-1 antibody; gluR-A antibody; gluR-K1 antibody; glutamate receptor 1 antibody; AMPA1 / GLUR1 (aa264-277)

other names :

glutamate receptor 1 isoform 1; Glutamate receptor 1; glutamate receptor 1; glutamate ionotropic receptor AMPA type subunit 1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic, AMPA 1; GluA1

products gene name :

GRIA1

products gene name syn :

AMPA1; GLUR1

other gene names :

GRIA1; GRIA1; GLUH1; GLUR1; GLURA; GluA1; HBGR1; GLUH1; GLUR1; GluR-1; GluA1

uniprot entry name :

GRIA1_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

sequence length :

906

sequence :

KIMQQWKNSDARD

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 100kDa band observed in Human, Mouse and Rat Brain (Cerebellum) lysates (calculated MW of 102kDa according to NP_000818.2). Recommended concentration: 0.1-0.3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-KIMQQWKNSDARD, from the internal region of the protein sequence according to NP_000818.2; NP_001107655.1. Epitope: Internal region

other info2 :

Note: This antibody is expected to recognize both reported isoforms (NP_000818.2; NP_001107655.1).

ncbi gi num :

167001419

ncbi acc num :

NP_000818.2

ncbi gb acc num :

NM_000827.3

ncbi mol weight :

102,864 Da

ncbi pathways :

Activation Of AMPA Receptors Pathway (1268797); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (1268798); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Asparagine N-linked Glycosylation Pathway (1268714); BDNF Signaling Pathway (712093); COPII (Coat Protein 2) Mediated Vesicle Transport Pathway (1268727)

ncbi summary :

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

GluR1: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Expressed in granule and pyramidal cells in the hippocampal formation. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated; Channel, calcium. Chromosomal Location of Human Ortholog: 5q31.1. Cellular Component: cell junction; cell soma; cell surface; dendrite; dendritic spine; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; Golgi membrane; plasma membrane; postsynaptic density; postsynaptic membrane; recycling endosome; synaptic vesicle. Molecular Function: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; excitatory extracellular ligand-gated ion channel activity; extracellular-glutamate-gated ion channel activity; glutamate receptor activity; PDZ domain binding; protein binding. Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; ionotropic glutamate receptor signaling pathway; long-term memory; receptor internalization; signal transduction; synaptic transmission

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage