catalog number :
MBS422607
products full name :
Goat anti-RSPO3 Antibody
products short name :
RSPO3
products name syn :
CRISTIN1; FLJ14440; PWTSR; R-spondin 3; R-spondin 3 homolog (Xenopus laevis); thrombospondin; type I; domain containing 2; thrombospondin-like; THSD2; RSPO3; RSPO3; R-spondin 3 homolog (Xenopus laevis); CRISTIN1; FLJ14440; PWTSR; THSD2; R-spondin 3; thrombospondin, type I, domain containing 2; thrombospondin-like
other names :
R-spondin-3; R-spondin-3; R-spondin-3; R-spondin 3 homolog; roof plate-specific spondin-3; protein with TSP type-1 repeat; thrombospondin, type I, domain containing 2; thrombospondin type-1 domain-containing protein 2; R-spondin 3; Protein with TSP type-1 repeat; hPWTSR; Roof plate-specific spondin-3; hRspo3; Thrombospondin type-1 domain-containing protein 2
products gene name :
RSPO3
other gene names :
RSPO3; RSPO3; PWTSR; THSD2; CRISTIN1; PWTSR; THSD2; hPWTSR; hRspo3
uniprot entry name :
RSPO3_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 28kDa band observed in Human Skeletal Muscle lysates (calculated MW of 30.9kDa according to NP_116173.2). Recommended concentration: 0.3-1ug/ml. Peptide ELISA: antibody detection limit dilution 1:8000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence QHPSAKGNLCPPT, from the internal region of the protein sequence according to NP_116173.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS427629
ncbi acc num :
NP_116173.2
ncbi gb acc num :
NM_032784.4
ncbi mol weight :
33,233 Da
ncbi pathways :
Disease Pathway 530764!!RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway 1016209!!Signal Transduction Pathway 477114!!Signaling By WNT In Cancer Pathway 1016191!!Signaling By Wnt Pathway 106510!!TCF Dependent Signaling In Response To WNT Pathway 980475!!XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway 1016210!!Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway 1016208!!Regulation Of FZD By Ubiquitination Pathway 980483
ncbi summary :
This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]