antibody

Goat anti-Doublecortin / DCX (aa232-242) Antibody

MBS422562

0.1 mg

290 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog, cow

western blot, enzyme immunoassay

Antibody

Goat anti-Doublecortin / DCX (aa232-242) Antibody

Doublecortin/DCX

DCX; doublecortin; RP5-914P14.1; DBCN; DC; FLJ51296; LISX; SCLH; XLIS; OTTHUMP00000216316; doublecortex; doublin; lis-X; lissencephalin-X; neuronal migration protein doublecortin; Goat Anti-Doublecortin (mouse); DCX; doublecortin; RP5-914P14.1; DBCN; DC; FLJ51296; LISX; SCLH; XLIS; OTTHUMP00000023860; OTTHUMP00000216316; doublecortex; doublin; lis-X; lissencephalin-X; neuronal migration protein doublecortin

neuronal migration protein doublecortin isoform a; Neuronal migration protein doublecortin; neuronal migration protein doublecortin; lis-X; doublin; doublecortex; lissencephalin-X; doublecortin; Doublin; Lissencephalin-X; Lis-X

DCX

DCX; DCX; DC; DBCN; LISX; SCLH; XLIS; DBCN; LISX; Lis-X

DCX_HUMAN

Polyclonal

Goat

Human, Mouse, Rat, Dog, Pig, Cow

441

KTSANMKAPQS

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Western Blot: Approx 45kDa band observed in Mouse fetal Brain lysates (calculated MW of 49.3kDa according to Human NP_000546.2 and 40.6kDa according to Human NP_835365.1 and Mouse NP_001103692.1). Recommended concentration: 0.01-0.03ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.

Epitope: Internal Region. Immunogen: Peptide with sequence C-KTSANMKAPQS, from the internal region of the protein sequence according to NP_000546.2; NP_835365.1; NP_835364.1; NP_001182482.1. Corresponding Immunizing Peptide: Catalog #MBS427677

Important Note: This antibody is expected to recognize all four reported isoforms (NP_000546.2; NP_835365.1; NP_835364.1; NP_001182482.1). Reported variants represent identical protein: NP_835364.1 and NP_835366.1.

30181246

NP_000546.2

NM_000555.3

40,215 Da

Axon Guidance Pathway 105688!!Developmental Biology Pathway 477129!!L1CAM Interactions Pathway 161003!!Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway 137984!!Neurofascin Interactions Pathway 161008

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

0.1 mg

290 USD