antibody

Goat anti-BIRC3 Antibody

MBS422528

0.1 mg

300 USD

polyclonal

goat

nonconjugated

human, rat

western blot, enzyme immunoassay

Antibody

Goat anti-BIRC3 Antibody

BIRC3

Goat Anti-BIRC3 (aa 109 -118) Antibody; BIRC3; baculoviral IAP repeat-containing 3; AIP1; API2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49; c-IAP2; TNFR2-TRAF signaling complex protein; apoptosis inhibitor 2; baculoviral IAP repeat-containing protein 3; inhibitor of apoptosis protein 1; mammalian; AIP1 antibody; API2 antibody; apoptosis inhibitor 2 antibody; baculoviral IAP repeat-containing 3 antibody; baculoviral IAP repeat-containing protein 3 antibody; CIAP2 antibody; c-IAP2 antibody; HAIP1 antibody; HIAP1 antibody; MALT2 antibody; MIHC antibody; RNF49 antibody; TNFR2-TRAF signaling complex protein antibody; BIRC3 antibody

baculoviral IAP repeat-containing protein 3; Baculoviral IAP repeat-containing protein 3; baculoviral IAP repeat-containing protein 3; baculoviral IAP repeat containing 3; Apoptosis inhibitor 2; API2; C-IAP2; IAP homolog C; Inhibitor of apoptosis protein 1; IAP-1; hIAP-1; hIAP1; RING finger protein 49; TNFR2-TRAF-signaling complex protein 1

BIRC3

BIRC3; BIRC3; AIP1; API2; MIHC; CIAP2; HAIP1; HIAP1; MALT2; RNF49; c-IAP2; API2; IAP1; MIHC; RNF49; API2; IAP-1; hIAP-1; hIAP1

BIRC3_HUMAN

Polyclonal

Goat

Tested: Rat; Expected from sequence similarity: Human

604

SVNNLEATSQP

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Experiments gave bands at approx 70kDa and 52kDa in Rat Testis lysates. These bands correspond to earlier findings with different antibodies from other commercial sources. This protein has a calculated MW of 67.3kDa according to Rat NP_076477.2. Recommended concentration: 1-3ug/ml.

Immunogen: Peptide with sequence C-SVNNLEATSQP, from the internal region of the protein sequence according to NP_001156.1. Epitope: Internal region

Note: Reported variants represent identical protein: NP_892007.1, NP_001156.1.

4502139

NP_001156.1

NM_001165.4

68,372 Da

Activated TLR4 Signalling Pathway (1269236); Apoptosis Pathway (198797); Apoptosis Pathway (83060); Apoptosis Pathway (470); Apoptosis - Multiple Species Pathway (1384747); Apoptosis - Multiple Species Pathway (1384709); Apoptosis Modulation And Signaling Pathway (198822); C-MYB Transcription Factor Network Pathway (138073); CD40/CD40L Signaling Pathway (138061); Caspase Cascade In Apoptosis Pathway (137974)

This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]

cIAP2: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase- independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Interacts with RIP1, RIP2, RIP3, RIP4 and USP19. Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes. USP19 regulates the stability of BIRC3/c-IAP2 by preventing its ubiquitination. Belongs to the IAP family. Protein type: Apoptosis; Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.-; Ligase. Chromosomal Location of Human Ortholog: 11q22. Cellular Component: cytoplasm; cytosol; lipid raft; nucleoplasm; nucleus; protein complex; spindle microtubule. Molecular Function: caspase inhibitor activity; ligase activity; protein binding; transferase activity; ubiquitin-protein ligase activity; zinc ion binding. Biological Process: cell surface receptor linked signal transduction; I-kappaB kinase/NF-kappaB cascade; negative regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein ubiquitination; protein heterooligomerization; protein ubiquitination; regulation of apoptosis; regulation of inflammatory response; regulation of innate immune response; regulation of toll-like receptor signaling pathway; spermatogenesis; tumor necrosis factor-mediated signaling pathway

0.1 mg

300 USD