catalog number :
MBS422502
products full name :
Goat anti-PCSK9 (aa214-228) Antibody
products short name :
PCSK9
products name syn :
PCSK9; proprotein convertase subtilisin/kexin type 9; FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; OTTHUMP00000009833; convertase subtilisin/kexin type 9 preproprotein; hypercholesterolemia; autosomal dominant 3; neural apoptosis regulated convertase 1; Goat Anti-PCSK9 (C Terminus); PCSK9; proprotein convertase subtilisin/kexin type 9; FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; OTTHUMP00000009833; convertase subtilisin/kexin type 9 preproprotein; hypercholesterolemia, autosomal dominant 3; neural apoptosis regulated convertase 1
other names :
proprotein convertase subtilisin/kexin type 9 preproprotein; Proprotein convertase subtilisin/kexin type 9; proprotein convertase subtilisin/kexin type 9; subtilisin/kexin-like protease PC9; neural apoptosis regulated convertase 1; convertase subtilisin/kexin type 9 preproprotein; proprotein convertase subtilisin/kexin type 9; Neural apoptosis-regulated convertase 1; NARC-1; Proprotein convertase 9; PC9; Subtilisin/kexin-like protease PC9
products gene name :
PCSK9
other gene names :
PCSK9; PCSK9; FH3; PC9; NARC1; LDLCQ1; NARC-1; HCHOLA3; NARC1; NARC-1; PC9
uniprot entry name :
PCSK9_HUMAN
reactivity :
Human, Mouse, Rat
sequence :
TRFHRQASKCDSHGT
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB-Trf)
app notes :
Western Blot: In transfected HEK293 transiently expressing full-length Human PCSK9 (myc and DYKDDDDK tagged), a doublet of approx. 80-100kDa was observed. No bands were observed in mock-transfected HEK293 and the same bands were observed using anti-myc tag antibody. Recommended concentration, 0.1-0.5ug/ml. Peptide ELISA: antibody detection limit dilution 1:16000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence TRFHRQASKCDSHGT, from the internal region of the protein sequence according to NP_777596.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS427583
ncbi acc num :
NP_777596.2
ncbi gb acc num :
NM_174936.3
ncbi mol weight :
20,827 Da
ncbi summary :
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]