catalog number :
MBS422478
products full name :
Goat anti-BCL2A1 Antibody
products short name :
BCL2A1
products name syn :
ACC-1; ACC-2; BCL2L5; BCL2-related protein A1; BFL1; GRS; HBPA1; hematopoietic BCL2-related protein A1; BCL2A1; BCL2A1; BCL2-related protein A1; ACC-1; ACC-2; BCL2L5; BFL1; GRS; HBPA1; hematopoietic BCL2-related protein A1
other names :
bcl-2-related protein A1 isoform 1; Bcl-2-related protein A1; bcl-2-related protein A1; bcl2-L-5; protein BFL-1; bcl-2-like protein 5; hematopoietic BCL2-related protein A1; hemopoietic-specific early response protein; BCL2-related protein A1; Bcl-2-like protein 5; Bcl2-L-5; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS
products gene name :
BCL2A1
other gene names :
BCL2A1; BCL2A1; GRS; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5; BCL2L5; BFL1; GRS; HBPA1; Bcl2-L-5
uniprot entry name :
B2LA1_HUMAN
reactivity :
Human, Dog, Cow, Pig
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 20kDa band observed in Human Bone Marrow lysates (calculated MW of 20.1kDa according to NP_004040.1). Recommended concentration: 0.1-0.3ug/ml. Peptide ELISA: antibody detection limit dilution 1:8000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-NVVSVDTART, from the internal region of the protein sequence according to NP_004040.1; NP_001108207.1. Corresponding Immunizing Peptide: Catalog #MBS427721
other info2 :
Important Note: This antibody is expected to recognize both reported isoforms (NP_004040.1; NP_001108207.1).
ncbi acc num :
NP_004040.1
ncbi gb acc num :
NM_004049.3
ncbi mol weight :
18,746 Da
ncbi pathways :
Apoptosis Modulation And Signaling Pathway 198822!!BCR Signaling Pathway 138058!!Direct P53 Effectors Pathway 137939!!NF-kappa B Signaling Pathway 634527!!Transcriptional Misregulation In Cancer Pathway 523016!!Transcriptional Misregulation In Cancer Pathway 522987
ncbi summary :
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]