catalog number :
MBS422476
products full name :
Goat anti-ALDH18A1 Antibody
products short name :
ALDH18A1
products name syn :
aldehyde dehydrogenase 18 family; member A1; aldehyde dehydrogenase 18A1; delta1-pyrroline-5-carboxlate synthetase; GSAS; MGC117316; P5CS; PYCS; pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase); ALDH18A1; aldehyde dehydrogenase 18 family, member A1; GSAS; MGC117316; P5CS; PYCS; aldehyde dehydrogenase 18A1; delta1-pyrroline-5-carboxlate synthetase; pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase)
other names :
delta-1-pyrroline-5-carboxylate synthase isoform 1; Delta-1-pyrroline-5-carboxylate synthase; delta-1-pyrroline-5-carboxylate synthase; delta1-pyrroline-5-carboxlate synthetase; aldehyde dehydrogenase family 18 member A1; delta-1-pyrroline-5-carboxylate synthetase; pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase); aldehyde dehydrogenase 18 family, member A1; Aldehyde dehydrogenase family 18 member A1Including the following 2 domains:Glutamate 5-kinase (EC:2.7.2.11); GKAlternative name(s):Gamma-glutamyl kinase
products gene name :
ALDH18A1
other gene names :
ALDH18A1; ALDH18A1; GSAS; P5CS; PYCS; ARCL3A; GSAS; P5CS; PYCS; P5CS; GK; GPR
uniprot entry name :
P5CS_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Cow, Pig
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 85kDa band observed in lysates of cell lines NIH3T3 and MCF7 (calculated MW of 87.3kDa according to NP_002851.2). Recommended concentration: 1-3ug/ml. Peptide ELISA: antibody detection limit dilution 1:8000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-SEHGSLKYLH, from the C Terminus of the protein sequence according to NP_002851.2; NP_001017423.1. Corresponding Immunizing Peptide: Catalog #MBS427422
other info2 :
Important Note: This antibody is expected to recognize both reported isoforms (NP_002851.2; NP_001017423.1).
ncbi acc num :
NP_002851.2
ncbi gb acc num :
NM_002860.3
ncbi mol weight :
87,089 Da
ncbi pathways :
Amino Acid Synthesis And Interconversion (transamination) Pathway 106173!!Arginine And Proline Metabolism Pathway 82957!!Arginine And Proline Metabolism Pathway 323!!Biosynthesis Of Amino Acids Pathway 790012!!Biosynthesis Of Amino Acids Pathway 795174!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Amino Acids And Derivatives Pathway 106169!!Proline Biosynthesis, Glutamate = Proline Pathway 413349!!Proline Biosynthesis, Glutamate = Proline Pathway 468208
ncbi summary :
This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene. [provided by RefSeq, Jul 2008]