antibody

Goat anti-PRKAA2 Antibody

MBS422445

0.1 mg

290 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog, cow

western blot, ELISA, enzyme immunoassay

Antibody

Goat anti-PRKAA2 Antibody

PRKAA2

5 -AMP-activated protein kinase; catalytic alpha-2 chain; AMP-activated protein kinase alpha 2 catalytic subunit; AMPK; AMPK2; AMPK-alpha-2 chain; PRKAA; protein kinase; AMP-activated; alpha 2 catalytic subunit; PRKAA2; PRKAA2; protein kinase, AMP-activated, alpha 2 catalytic subunit; AMPK; AMPK2; PRKAA; 5'-AMP-activated protein kinase, catalytic alpha-2 chain; AMP-activated protein kinase alpha 2 catalytic subunit; AMPK-alpha-2 chain

5'-AMP-activated protein kinase catalytic subunit alpha-2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; ACACA kinase; AMPK alpha 2; HMGCR kinase; AMPK-alpha-2 chain; AMPK subunit alpha-2; acetyl-CoA carboxylase kinase; hydroxymethylglutaryl-CoA reductase kinase; AMP-activated protein kinase alpha-2 subunit variant 2; AMP-activated protein kinase alpha-2 subunit variant 3; 5'-AMP-activated protein kinase, catalytic alpha-2 chain; protein kinase, AMP-activated, alpha 2 catalytic subunit; Acetyl-CoA carboxylase kinase (EC:2.7.11.27); ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase (EC:2.7.11.31); HMGCR kinase

PRKAA2

PRKAA2; PRKAA2; AMPK; AMPK2; PRKAA; AMPKa2; AMPK; AMPK2; AMPK subunit alpha-2; ACACA kinase; HMGCR kinase

AAPK2_HUMAN

Polyclonal

Goat

Human, Mouse, Rat, Dog, Pig, Cow

552

CPLDALNTTKP

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB), ELISA (EIA)

Western Blot: Approx 65kDa band observed in Human Heart and Liver lysates and in Mouse and Rat Heart lysates (calculated MW of 62.3kDa according to NP_006243.2). Recommended concentration: 0.3-1ug/ml. Peptide ELISA: antibody detection limit dilution 1:16000. Enzyme immunoassay: Sandwich-type ELISA with increasing amount of recombinant PRKAA2 captured by a rabbit antibody. Recommended reporter concentration: 1.5-3ug/ml

Epitope: Internal Region. Immunogen: Peptide with sequence CPLDALNTTKP, from the internal region of the protein sequence according to NP_006243.2.

Corresponding Immunizing Peptide: Catalog #MBS427385

46877068

NP_006243.2

NM_006252.3

62,320 Da

AMPK Inhibits ChREBP Transcriptional Activation Activity Pathway 106102!!AMPK Signaling Pathway 198868!!AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Activation Of PPARGC1A (PGC-1alpha) By Phosphorylation Pathway 980487!!Adipocytokine Signaling Pathway 83093!!Adipocytokine Signaling Pathway 505!!BDNF Signaling Pathway 712093!!Circadian Rhythm Pathway 83084!!Circadian Rhythm Pathway 495

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]

0.1 mg

290 USD