Goat anti-NDUFS2 Antibody | MyBioSource MBS422418 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-NDUFS2 Antibody

catalog :

MBS422418

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS422418

products type :

Antibody

products full name :

Goat anti-NDUFS2 Antibody

products short name :

NDUFS2

products name syn :

NDUFS2; NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe-S protein 2; NADH-ubiquinone oxidoreductase NDUFS2 subunit; complex 1, mitochondrial respiratory chain, 49-KD subunit; complex 1; mitochondrial respiratory chain; 49-KD subunit antibody; NADH dehydrogenase (ubiquinone) Fe-S protein 2 antibody; NADH dehydrogenase (ubiquinone) Fe-S protein 2; 49kDa (NADH-coenzyme Q reductase) antibody; NADH-ubiquinone oxidoreductase NDUFS2 subunit antibody; NDUFS2 antibody

other names :

NADH dehydrogenase; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; NADH:ubiquinone oxidoreductase core subunit S2; Complex I-49kD; CI-49kD; NADH-ubiquinone oxidoreductase 49 kDa subunit

products gene name :

NDUFS2

other gene names :

NDUFS2; NDUFS2; CI-49; CI-49kD

uniprot entry name :

NDUS2_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow, Pig, Rabbit

sequence length :

463

sequence :

SRGVRQWQPDVE

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 48kDa band observed in Human, Mouse and Rat Heart lysates (calculated MW of 51.9kDa according to NP_001159631.1). Recommended concentration: 0.1-0.3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-SRGVRQWQPDVE, from the internal region of the protein sequence according to NP_004541.1; NP_001159631.1. Epitope: Internal region

other info2 :

Note: This antibody is expected to recognize both reported isoforms (NP_004541.1; NP_001159631.1).

ncbi gi num :

4758786

ncbi acc num :

NP_004541.1

ncbi gb acc num :

NM_004550.4

ncbi mol weight :

51,852 Da

ncbi pathways :

Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Complex I Biogenesis Pathway (1339146); Electron Transport Chain Pathway (198860); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Metabolic Pathways (132956); Metabolism Pathway (1269956); NADH Dehydrogenase (ubiquinone) Fe-S Protein/flavoprotein Complex, Mitochondria Pathway (413407); NADH Dehydrogenase (ubiquinone) Fe-S Protein/flavoprotein Complex, Mitochondria Pathway (890441)

ncbi summary :

The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

uniprot summary :

NDUFS2: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Defects in NDUFS2 are a cause of mitochondrial complex I deficiency (MT-C1D). A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. Belongs to the complex I 49 kDa subunit family. Protein type: Oxidoreductase; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; EC 1.6.5.3. Chromosomal Location of Human Ortholog: 1q23. Cellular Component: mitochondrial matrix; mitochondrial respiratory chain complex I; mitochondrion; nucleoplasm. Molecular Function: 4 iron, 4 sulfur cluster binding; electron carrier activity; metal ion binding; NAD binding; NADH dehydrogenase (ubiquinone) activity; NADH dehydrogenase activity; protein binding; quinone binding; ubiquitin protein ligase binding. Biological Process: mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; response to oxidative stress. Disease: Mitochondrial Complex I Deficiency

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage