catalog number :
MBS422401
products full name :
Goat anti-FANCL Antibody
products short name :
FANCL
products name syn :
FAAP43; Fanconi anemia; complementation group L; FLJ10335; PHD finger protein 9; PHF9; POG; FANCL; FANCL; Fanconi anemia, complementation group L; FAAP43; FLJ10335; PHF9; POG; PHD finger protein 9
other names :
E3 ubiquitin-protein ligase FANCL isoform 1; E3 ubiquitin-protein ligase FANCL; E3 ubiquitin-protein ligase FANCL; PHD finger protein 9; fanconi anemia group L protein; fanconi anemia-associated polypeptide of 43 kDa; Fanconi anemia, complementation group L; Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kDa; FAAP43
products gene name :
FANCL
other gene names :
FANCL; FANCL; POG; PHF9; FAAP43; PHF9; FAAP43
uniprot entry name :
FANCL_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 45kDa band observed in Human Bone Marrow lysates (calculated MW of 43.4kDa according to NP_001108108.1). Recommended concentration: 1-3ug/ml. Peptide ELISA: antibody detection limit dilution 1:16000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-QNLKDVLEIDFP, from the internal region of the protein sequence according to NP_001108108.1; NP_060532.2. Corresponding Immunizing Peptide: Catalog #MBS427286
other info2 :
Important Note: This antibody is expected to recognize both isoforms (NP_001108108.1; NP_060532.2).
ncbi acc num :
NP_001108108.1
ncbi gb acc num :
NM_001114636.1
ncbi mol weight :
43,430 Da
ncbi pathways :
BARD1 Signaling Events Pathway 137959!!DNA Repair Pathway 105837!!FA Core Complex Pathway 413476!!FA Core Complex Pathway 890628!!Fanconi Anemia Pathway 105895!!Fanconi Anemia Pathway 377262!!Fanconi Anemia Pathway 377128!!Ubiquitin Mediated Proteolysis Pathway 83056!!Ubiquitin Mediated Proteolysis Pathway 466
ncbi summary :
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]