catalog number :
MBS422393
products full name :
Goat anti-ALDH2 Antibody
products short name :
ALDH2
products name syn :
acetaldehyde dehydrogenase 2; aldehyde dehydrogenase 2 family (mitochondrial); ALDH class 2; ALDH-E2; ALDHI; ALDM; liver mitochondrial ALDH; MGC1806; mitochondrial aldehyde dehydrogenase 2; nucleus-encoded mitochondrial aldehyde dehydrogenase 2; ALDH2; aldehyde dehydrogenase 2 family (mitochondrial); ALDH-E2; ALDHI; ALDM; MGC1806; ALDH class 2; acetaldehyde dehydrogenase 2; liver mitochondrial ALDH; mitochondrial aldehyde dehydrogenase 2; nucleus-encoded mitochondrial aldehyde dehydrogenase 2
other names :
aldehyde dehydrogenase, mitochondrial isoform 1; Aldehyde dehydrogenase, mitochondrial; aldehyde dehydrogenase, mitochondrial; ALDH class 2; liver mitochondrial ALDH; acetaldehyde dehydrogenase 2; nucleus-encoded mitochondrial aldehyde dehydrogenase 2; aldehyde dehydrogenase 2 family (mitochondrial); ALDH class 2; ALDH-E2; ALDHI
products gene name :
ALDH2
other gene names :
ALDH2; ALDH2; ALDM; ALDHI; ALDH-E2; ALDM
uniprot entry name :
ALDH2_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Cow, Pig
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB), ELISA (EIA)
app notes :
Western Blot: Approx 50kDa band observed in Human, Mouse and Rat Liver lysates (calculated MW of 56.4kDa according to Human NP_000681.2 amd 56.5kDa according to Mouse NP_033786.1). Recommended concentration: 0.03-0.1ug/ml. Peptide ELISA: antibody detection limit dilution 1:8000. Enzyme immunoassay: Sandwich-type ELISA with increasing amount of recombinant ALDH2 captured by a rabbit antibody. Recommended reporter concentration: 1-2ug/ml
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-DETQFKKILGYIN, from the internal region of the protein sequence according to NP_000681.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS427356
ncbi acc num :
NP_000681.2
ncbi gb acc num :
NM_000690.3
ncbi mol weight :
50,989 Da
ncbi pathways :
Arginine And Proline Metabolism Pathway 82957!!Arginine And Proline Metabolism Pathway 323!!Ascorbate And Aldarate Metabolism Pathway 82932!!Ascorbate And Aldarate Metabolism Pathway 293!!Biological Oxidations Pathway 105698!!Ethanol Oxidation Pathway 105715!!Fatty Acid Omega Oxidation Pathway 198915!!Fatty Acid Degradation Pathway 82935!!Fatty Acid Degradation Pathway 296!!GABA Biosynthesis, Eukaryotes, Putrescine = GABA Pathway 413399
ncbi summary :
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]