catalog number :
MBS422328
products full name :
Goat anti-ARMS2 Antibody
products short name :
ARMS2
products name syn :
ARMS2; age-related maculopathy susceptibility 2; ARMD8; age-related maculopathy susceptibility 2 antibody; ARMD8 antibody; ARMS2 antibody
other names :
age-related maculopathy susceptibility protein 2; Age-related maculopathy susceptibility protein 2; age-related maculopathy susceptibility protein 2; age-related maculopathy susceptibility 2
products gene name :
ARMS2
other gene names :
ARMS2; ARMS2; ARMD8
uniprot entry name :
ARMS2_HUMAN
reactivity :
Expected from sequence similarity: Human
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 4000. Western Blot: Not yet tested - our routinely used western blotting protocol does not allow detection of proteins as small as the calculated size of 11.4kDa according to NP_001093137.1. Therefore we cannot recommend an optimal concentration and the antibody is an aspiring product.
other info1 :
Immunogen: Peptide with sequence C-EGASDKQRSK, from the internal region of the protein sequence according to NP_001093137.1. Epitope: Internal region
ncbi acc num :
NP_001093137.1
ncbi gb acc num :
NM_001099667.1
ncbi mol weight :
11,437 Da
ncbi summary :
This gene encodes a protein that is thought to play a role in diseases in the elderly. Mutations in this gene have been associated with age-related macular degeneration. [provided by RefSeq, Oct 2008]
uniprot summary :
ARMS2: Defects in ARMS2 influence susceptibility to age-related macular degeneration type 8 (ARMD8). ARMD is the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch's membrane. ARMD is likely to be a mechanistically heterogeneous group of disorders, and the specific disease mechanisms that underlie the vast majority of cases are currently unknown. However, a number of studies have suggested that both genetic and environmental factors are likely to play a role. Chromosomal Location of Human Ortholog: 10q26.13. Cellular Component: mitochondrion; photoreceptor inner segment. Biological Process: retinal homeostasis. Disease: Macular Degeneration, Age-related, 8