Goat anti-Cryopirin / NALP3 / NLRP3 Antibody | MyBioSource MBS422321 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Cryopirin / NALP3 / NLRP3 Antibody

catalog :

MBS422321

quantity :

0.1 mg

price :

225 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, dog, cow

application :

enzyme immunoassay

product information

catalog number :

MBS422321

products type :

Antibody

products full name :

Goat anti-Cryopirin / NALP3 / NLRP3 Antibody

products short name :

Cryopirin/NALP3/NLRP3

products name syn :

AGTAVPRL; AII; AII/AVP; AII/AVP receptor-like; AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCU; FLJ95925; MWS; NACHT domain-; leucine-rich repeat-; and PYD-containing protein 3; NACHT; LRR and PYD contain; NALP3; NLR family; pyrin domain containing 3; NLRP3; Goat Anti-CIAS1 / Cryopyrin (Internal); NLRP3; NLR family, pyrin domain containing 3; AGTAVPRL; AII; AII/AVP; AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCU; FLJ95925; MWS; NALP3; PYPAF1; AII/AVP receptor-like; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; NACHT, LRR and PYD contain

other names :

NACHT, LRR and PYD domains-containing protein 3 isoform a; NACHT, LRR and PYD domains-containing protein 3; NACHT, LRR and PYD domains-containing protein 3; cryopyrin; caterpiller protein 1.1; PYRIN-containing APAF1-like protein 1; NACHT, LRR and PYD containing protein 3; cold autoinflammatory syndrome 1 protein; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3; NLR family, pyrin domain containing 3; Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; CLR1.1; Cold autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1

products gene name :

NLRP3

other gene names :

NLRP3; NLRP3; AII; AVP; FCU; MWS; FCAS; CIAS1; FCAS1; NALP3; C1orf7; CLR1.1; PYPAF1; AGTAVPRL; C1orf7; CIAS1; NALP3; PYPAF1; CLR1.1

uniprot entry name :

NALP3_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Human, Dog, Cow

sequence length :

1036

sequence :

RDLYEKAKRDEPK

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA)

app notes :

Western Blot: Preliminary experiments gave an approx 36kDa band in Human Peripheral Blood Mononucleocytes lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the smallest calculated size of 106kDa according to NP_899632.1. The 36kDa band was successfully blocked by incubation with the immunizing peptide. Peptide ELISA: antibody detection limit dilution 1:32000.

other info1 :

Epitope: N-Terminus (near). Immunogen: Peptide with sequence RDLYEKAKRDEPK-C, from the N-Terminus (near) of the protein sequence according to NP_004886.3; NP_899632.1; NP_001120933.1; NP_001120934.1. Corresponding Immunizing Peptide: Catalog #MBS427226

other info2 :

Important Note: This antibody is expected to recognize all reported isoforms (NP_004886.3; NP_899632.1; NP_001120933.1; NP_001120934.1). Reported variants NP_001073289.1 and NP_004886.3 represent identical protein.

ncbi gi num :

34878693

ncbi acc num :

NP_004886.3

ncbi gb acc num :

NM_004895.4

ncbi mol weight :

115,968 Da

ncbi pathways :

Immune System Pathway 106386!!Inflammasomes Pathway 366166!!Influenza A Pathway 217173!!Influenza A Pathway 217150!!Innate Immune System Pathway 106387!!NOD Pathway 198792!!NOD-like Receptor Signaling Pathway 122191!!NOD-like Receptor Signaling Pathway 122131!!Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways 366164!!Pertussis Pathway 218111

ncbi summary :

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]

size :

0.1 mg

price :

225 USD