catalog number :
MBS422319
products full name :
Goat anti-PIAS2 (aa185-196) Antibody
products short name :
PIAS2
products name syn :
MGC102682; miz; MIZ1; Msx-interacting-zinc finger; PIASX; PIASX-ALPHA; PIASX-BETA; protein inhibitor of activated STAT X; protein inhibitor of activated STAT; 2; SIZ2; zinc finger; MIZ-type containing 4; ZMIZ4; PIAS2; Goat Anti-PIAS2; PIAS2; protein inhibitor of activated STAT, 2; MGC102682; MIZ1; PIASX; PIASX-ALPHA; PIASX-BETA; SIZ2; ZMIZ4; miz; Msx-interacting-zinc finger; protein inhibitor of activated STAT X; zinc finger, MIZ-type containing 4
other names :
E3 SUMO-protein ligase PIAS2 isoform alpha; E3 SUMO-protein ligase PIAS2; E3 SUMO-protein ligase PIAS2; DAB2-interacting protein; zinc finger, MIZ-type containing 4; msx-interacting zinc finger protein; protein inhibitor of activated STAT X; androgen receptor-interacting protein 3; protein inhibitor of activated STAT, 2; Androgen receptor-interacting protein 3; ARIP3; DAB2-interacting protein; DIP; Msx-interacting zinc finger protein; Miz1; PIAS-NY protein; Protein inhibitor of activated STAT x; Protein inhibitor of activated STAT2
products gene name :
PIAS2
other gene names :
PIAS2; PIAS2; DIP; MIZ; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4; PIASX-BETA; PIASX-ALPHA; PIASX; ARIP3; DIP; Miz1
uniprot entry name :
PIAS2_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 60kDa band observed in Human Spleen and Peripheral Mononucleocytes lysates (calculated MW of 63.4kDa according to NP_775298.1). Recommended concentration: 1-3ug/ml. Peptide ELISA: antibody detection limit dilution 1:16000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence PQQVREICISRD, from the internal region of the protein sequence according to NP_775298.1; NP_004662.2. Corresponding Immunizing Peptide: Catalog #MBS427224
other info2 :
Important Note: This antibody is expected to recognize both reported isoforms (NP_775298.1; NP_004662.2).
ncbi acc num :
NP_775298.1
ncbi gb acc num :
NM_173206.3
ncbi mol weight :
45,057 Da
ncbi pathways :
IL12 Signaling Mediated By STAT4 Pathway 137936!!Jak-STAT Signaling Pathway 83077!!Jak-STAT Signaling Pathway 488!!Pathways In Cancer 83105!!Small Cell Lung Cancer Pathway 83118!!Small Cell Lung Cancer Pathway 530!!Sumoylation By RanBP2 Regulates Transcriptional Repression Pathway 138029!!TGF-beta Receptor Signaling Pathway 198774!!Ubiquitin Mediated Proteolysis Pathway 83056!!Ubiquitin Mediated Proteolysis Pathway 466
ncbi summary :
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011]