catalog number :
MBS422284
products full name :
Goat anti-Mesothelin Antibody
products short name :
Mesothelin
products name syn :
MSLN; mesothelin; CAK1; MPF; SMR; megakaryocyte potentiating factor; CAK1 antibody; megakaryocyte potentiating factor antibody; mesothelin antibody; MPF antibody; SMR antibody; MSLN antibody; Mesothelin; Mesothelin
other names :
mesothelin isoform 1 preproprotein; Mesothelin; mesothelin; mesothelin; CAK1 antigen; Pre-pro-megakaryocyte-potentiating factor
products gene name :
MSLN
other gene names :
MSLN; MSLN; MPF; SMRP; MPF; MPF
uniprot entry name :
MSLN_HUMAN
reactivity :
Tested: Human; Expected from sequence similarity: Human
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 64000.
other info1 :
Immunogen: Peptide with sequence CPSGKKAREIDES, from the internal region of the protein sequence according to NP_005814.2; NP_037536.2. Epitope: Internal region
other info2 :
Note: This antibody is expected to recognize isoform 1 and 2 (NP_005814.2; NP_037536.2).
ncbi acc num :
NP_005814.2
ncbi gb acc num :
NM_005823.5
ncbi mol weight :
67,940 Da
ncbi summary :
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
uniprot summary :
MSLN: Membrane-anchored forms may play a role in cellular adhesion. Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. Belongs to the mesothelin family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion; Membrane protein, GPI anchor. Chromosomal Location of Human Ortholog: 16p13.3. Cellular Component: cell surface; extracellular space; Golgi apparatus; membrane; plasma membrane. Molecular Function: protein binding. Biological Process: cell adhesion; cell-matrix adhesion; pancreas development