catalog number :
MBS422255
products full name :
Goat anti-NOD1 / CARD4 Antibody
products short name :
NOD1/CARD4
products name syn :
CARD4; caspase recruitment domain family; member 4; NOD1; Nod1; caspase recruitment domain 4; NOD1; nucleotide-binding oligomerization domain containing 1; CARD4; CLR7.1; NLRC1; NLR family, CARD domain containing 1; caspase recruitment domain family, member 4; caspase recruitment domain-containing protein 4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1; nucleotide-binding oligomerization domain-containing protein 1
other names :
nucleotide-binding oligomerization domain-containing protein 1; Nucleotide-binding oligomerization domain-containing protein 1; nucleotide-binding oligomerization domain-containing protein 1; NLR family, CARD domain containing 1; caspase recruitment domain family, member 4; caspase recruitment domain-containing protein 4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1; nucleotide-binding oligomerization domain containing 1; Caspase recruitment domain-containing protein 4
products gene name :
NOD1
other gene names :
NOD1; NOD1; CARD4; NLRC1; CLR7.1; CARD4
uniprot entry name :
NOD1_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Pig, Cow
sequence :
EAKVYEDEKRIICF
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 85kDa band observed in Human Duodenum lysates (calculated MW of 107.6kDa according to NP_006083.1). Recommended concentration: 0.5-1.5ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence EAKVYEDEKRIICF, from the C Terminus of the protein sequence according to NP_006083.1.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS427338
ncbi acc num :
NP_006083.1
ncbi gb acc num :
NM_006092.2
ncbi mol weight :
27,949 Da
ncbi pathways :
Activated TLR4 Signalling Pathway 106400!!Cytokine Signaling In Immune System Pathway 366171!!Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway 83102!!Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway 515!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!Interleukin-1 Signaling Pathway 160141!!JNK (c-Jun Kinases) Phosphorylation And Activation Mediated By Activated Human TAK1 Pathway 160136!!MAP Kinase Activation In TLR Cascade Pathway 160135!!MyD88 Cascade Initiated On Plasma Membrane Pathway 205107
ncbi summary :
This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009]