Goat anti-KCNMA1 Antibody | MyBioSource MBS422248 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-KCNMA1 Antibody

catalog :

MBS422248

quantity :

0.1 mg

price :

225 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS422248

products type :

Antibody

products full name :

Goat anti-KCNMA1 Antibody

products short name :

KCNMA1

products name syn :

KCNMA1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; BKTM; DKFZp686K1437; KCa1.1; MGC71881; MaxiK; SAKCA; SLO; SLO-ALPHA; SLO1; mSLO1; BKCA alpha subunit; Drosophila slowpoke-like; OTTHUMP00000060198; OTTHUMP00000064; KCNMA1 antibody; potassium large conductance calcium-activated channel; subfamily M; alpha member 1 antibody; BKTM antibody; DKFZp686K1437 antibody; KCa1.1 antibody; MGC71881 antibody; MaxiK antibody; SAKCA antibody; SLO antibody; SLO-ALPHA antibody; SLO1 antibody; mSLO1 antibody; BKCA alpha subunit antibody; Drosophila slowpoke-like antibody; OTTHUMP00000060198 antibody; OTTHUMP00000064154 antibody; OTTHUMP00000064155 antibody; OTTHUMP00000064156 antibody; OTTHUMP00000064157 antibody; OTTHUMP00000064158 antibody; OTTHUMP00000064159 antibody; OTTHUMP00000064160 antibody; OTTHUMP00000064161 antibody; OTTHUMP00000064162 antibody; OTTHUMP00000064164 antibody; OTTHUMP00000064165 antibody; bA205K10.1 (potassium large conductance calcium-activaed channel; subfamily M; alpha member 1) antibody; large conductance calcium-activated potassium channel subfamily M alpha member 1 antibody; stretch-activated Kca channel antibody

other names :

calcium-activated potassium channel subunit alpha-1 isoform a; Calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel subunit alpha-1; uncharacterized protein; potassium calcium-activated channel subfamily M alpha 1; BK channel; BKCA alpha; Calcium-activated potassium channel, subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; MaxiK; Slo-alpha; Slo1; Slowpoke homolog; Slo homolog; hSlo

products gene name :

KCNMA1

other gene names :

KCNMA1; KCNMA1; SLO; BKTM; SLO1; hSlo; MaxiK; SAKCA; mSLO1; KCa1.1; SLO-ALPHA; bA205K10.1; KCNMA; SLO; MaxiK; Slo homolog; hSlo

uniprot entry name :

KCMA1_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Expected from sequence similarity: Human, Mouse, Rat, Cow

sequence length :

1182

sequence :

RESRDKQNRKEMVYR

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 2000. Western Blot: Preliminary experiments in Human Brain (Cerebellum, Cerebral Cortex, Frontal Cortex) lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).

other info1 :

Immunogen: Peptide with sequence C-RESRDKQNRKEMVYR, from the C Terminus of the protein sequence according to NP_001014797.1. Epitope: C Terminus

other info2 :

Note: This antibody is expected to recognize isoform a (NP_001014797.1) only.

ncbi gi num :

62388890

ncbi acc num :

NP_001014797.1

ncbi gb acc num :

NM_001014797.2

ncbi mol weight :

138,297 Da

ncbi pathways :

Ca2+ Activated K+ Channels Pathway (1268822); Hemostasis Pathway (1269340); Insulin Secretion Pathway (777534); Neuronal System Pathway (1268763); Nitric Oxide Stimulates Guanylate Cyclase Pathway (1269343); Pancreatic Secretion Pathway (169306); Pancreatic Secretion Pathway (169295); Platelet Homeostasis Pathway (1269341); Potassium Channels Pathway (1268821); Renin Secretion Pathway (1222951)

ncbi summary :

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

uniprot summary :

KCNMA1: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). Defects in KCNMA1 are the cause of generalized epilepsy and paroxysmal dyskinesia (GEPD). Epilepsy is one of the most common and debilitating neurological disorders. Paroxysmal dyskinesias are neurological disorders characterized by sudden, unpredictable, disabling attacks of involuntary movement often requiring life-long treatment. The coexistence of epilepsy and paroxysmal dyskinesia in the same individual or family is an increasingly recognized phenomenon. Patients manifest absence seizures, generalized tonic-clonic seizures, paroxysmal nonkinesigenic dyskinesia, involuntary dystonic or choreiform movements. Onset is usually in childhood and patients may have seizures only, dyskinesia only, or both. Belongs to the potassium channel family. Calcium- activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily. 7 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Endoplasmic reticulum; Membrane protein, integral; Channel, potassium. Chromosomal Location of Human Ortholog: 10q22.3. Cellular Component: apical plasma membrane; caveola; integral to membrane; plasma membrane; voltage-gated potassium channel complex. Molecular Function: actin binding; calcium-activated potassium channel activity; large conductance calcium-activated potassium channel activity; metal ion binding; protein binding; voltage-gated potassium channel activity. Biological Process: cellular potassium ion homeostasis; micturition; negative regulation of cell volume; positive regulation of apoptosis; potassium ion transport; regulation of membrane potential; response to calcium ion; response to hypoxia; response to osmotic stress; smooth muscle contraction involved in micturition. Disease: Generalized Epilepsy And Paroxysmal Dyskinesia

size1 :

0.1 mg

price1 :

225 USD

more info or order :

MyBioSource product webpage