catalog number :
MBS422235
products full name :
Goat anti-apolipoprotein A-IV (mouse) Antibody
products short name :
Apolipoprotein A-IV
products name syn :
Apoa4; apolipoprotein A-IV; Apoa-4; Apoa4 antibody; apolipoprotein A-IV antibody; Apoa-4 antibody; Apolipoprotein A-IV; apolipoprotein A-IV (mouse)
other names :
apolipoprotein A-IV; Apolipoprotein A-IV; apolipoprotein A-IV; apolipoprotein A-IV; Apolipoprotein A4
products gene name :
Apoa4
other gene names :
Apoa4; Apoa4; Apoa-4; Apo-AIV; ApoA-IV
uniprot entry name :
APOA4_MOUSE
reactivity :
Tested: Mouse; Expected from sequence similarity: Mouse, Rat
sequence :
QETERVKEEIKKELED
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Immunohistochemistry (IHC)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Preliminary experiments in Mouse and Rat Liver lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
other info1 :
Immunogen: Peptide with sequence C-QETERVKEEIKKELED, from the internal region of the protein sequence according to NP_031494.2. Epitope: Internal region
ncbi acc num :
NP_031494.2
ncbi gb acc num :
NM_007468.2
ncbi mol weight :
45,029 Da
ncbi pathways :
Chylomicron-mediated Lipid Transport Pathway (1367662); Fat Digestion And Absorption Pathway (194386); Fat Digestion And Absorption Pathway (194324); Lipid Digestion, Mobilization, And Transport Pathway (1367658); Lipoprotein Metabolism Pathway (1367661); Metabolism Pathway (1367614); Metabolism Of Fat-soluble Vitamins Pathway (1367813); Metabolism Of Lipids And Lipoproteins Pathway (1367657); Metabolism Of Vitamins And Cofactors Pathway (1367799); Retinoid Metabolism And Transport Pathway (1367135)
uniprot summary :
APOA4: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. Synthesized primarily in the intestine and secreted in plasma. Belongs to the apolipoprotein A1/A4/E family. Protein type: Secreted, signal peptide; Endoplasmic reticulum; Cell adhesion; Secreted; Lipid-binding. Cellular Component: cell surface; chylomicron; extracellular region; extracellular space. Molecular Function: antioxidant activity; cholesterol binding; cholesterol transporter activity; copper ion binding; lipid binding; phosphatidylcholine binding; protein homodimerization activity. Biological Process: cholesterol biosynthetic process; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; hydrogen peroxide catabolic process; innate immune response in mucosa; leukocyte adhesion; lipid homeostasis; lipid transport; lipoprotein metabolic process; multicellular organismal lipid catabolic process; neurite regeneration; phosphatidylcholine metabolic process; phospholipid efflux; positive regulation of fatty acid biosynthetic process; positive regulation of lipoprotein lipase activity; protein-lipid complex assembly; regulation of cholesterol absorption; regulation of cholesterol transport; removal of superoxide radicals; response to lipid hydroperoxide; reverse cholesterol transport; transport; triacylglycerol catabolic process