Goat anti-P2X4/P2X4R Antibody | MyBioSource MBS422225 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-P2X4/P2X4R Antibody

catalog :

MBS422225

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS422225

products type :

Antibody

products full name :

Goat anti-P2X4/P2X4R Antibody

products short name :

P2X4/P2X4R

products name syn :

Goat Anti-P2rx4 (mouse) Antibody; P2X4; P2X4R; P2RX4; purinergic receptor P2X, ligand-gated ion channel, 4; ATP receptor; ATP-gated cation channel protein; P2X purinoceptor 4; P2X receptor, subunit 4; purinergic receptor P2X ligand-gated ion channel 4; purinergic receptor P2X4; purinocept; P2X4 antibody; P2X4R antibody; P2RX4 antibody; purinergic receptor P2X; ligand-gated ion channel; 4 antibody; ATP receptor antibody; ATP-gated cation channel protein antibody; P2X purinoceptor 4 antibody; P2X receptor; subunit 4 antibody; purinergic receptor P2X ligand-gated ion channel 4 antibody; purinergic receptor P2X4 antibody; purinoceptor P2X4 antibody; P2X4 / P2X4R

other names :

P2X purinoceptor 4 isoform 2; P2X purinoceptor 4; P2X purinoceptor 4; purinergic receptor P2X 4; ATP receptor; Purinergic receptor

products gene name :

P2RX4

products gene name syn :

P2X4; P2X4R

other gene names :

P2RX4; P2RX4; P2X4; P2X4R; P2X4

uniprot entry name :

P2RX4_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

sequence length :

388

sequence :

YREKKYKYVEDYEQ

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Approx 60-70kDa band observed in Human Kideney, Liver and Rat Kidney (calculated MW of 43.4kDa according to NP_002551.2). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Brown et al, J Biol Chem.2004 Sep 17;279(38): 39485-94.; PMID: 15262999). Recommended concentration: 1-3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-YREKKYKYVEDYEQ, from the C Terminus of the protein sequence according to NP_002551.2. Epitope: C Terminus

ncbi gi num :

28416927

ncbi acc num :

NP_002551.2

ncbi gb acc num :

NM_002560.2

ncbi mol weight :

40,481 Da

ncbi pathways :

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Elevation Of Cytosolic Ca2+ Levels Pathway (1269346); Hemostasis Pathway (1269340); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Platelet Calcium Homeostasis Pathway (1269345); Platelet Homeostasis Pathway (1269341)

ncbi summary :

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

uniprot summary :

P2X4: Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. Belongs to the P2X receptor family. Protein type: Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 12q24.32. Cellular Component: cell junction; cell soma; dendritic spine; integral to nuclear inner membrane; integral to plasma membrane; lysosomal membrane; membrane; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; terminal button. Molecular Function: ATP binding; ATP-gated cation channel activity; cadherin binding; copper ion binding; drug binding; protein binding; protein homodimerization activity; purinergic nucleotide receptor activity; receptor binding; zinc ion binding. Biological Process: blood coagulation; endothelial cell activation; generation of action potential; membrane depolarization; positive regulation of calcium ion transport; positive regulation of calcium-mediated signaling; positive regulation of nitric oxide biosynthetic process; positive regulation of prostaglandin secretion; protein homooligomerization; regulation of blood pressure; regulation of sodium ion transport; response to ATP; sensory perception of pain; signal transduction; tissue homeostasis; transport

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage