catalog number : 
MBS422224
products full name : 
Goat anti-Synaptotagmin I Antibody
products short name : 
Synaptotagmin I
products name syn : 
synaptotagmin I; DKFZp781D2042; SYT1; P65; SVP65; SYT; synaptotagmin 1; synaptotagmin I; DKFZp781D2042; SYT1; P65; SVP65; SYT; synaptotagmin 1
other names : 
synaptotagmin-1 isoform 1; Synaptotagmin-1; synaptotagmin-1; sytI; synaptotagmin 1; synaptotagmin I; Synaptotagmin I; SytI; p65
products gene name : 
SYT1
other gene names : 
SYT1; SYT1; P65; SYT; SVP65; SVP65; SYT; SytI
uniprot entry name : 
SYT1_HUMAN
reactivity : 
Human, Mouse, Rat. Dog, Cow
purity : 
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form : 
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration : 
100ug specific antibody in 200ul
storage stability : 
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application : 
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes : 
Immunohistochemistry: In paraffin embedded Human Brain shows vesicular staining in neuronal cell and axon. Recommended concentration, 4-6ug/ml.  Western Blot: Approx. 65kDa band observed in Human Brain (hippocampus) and Mouse and Rat Brain lysates (calculated MW of 47.6kDa according to NP_005630.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Matthew et al, J Cell Biol. 1981 Oct;91(1):257-69.; PMID: 7298720). Recommended concentration: 0.3-1ug/ml.  Peptide ELISA: antibody detection limit dilution 1:2000.
other info1 : 
Epitope: Internal Region.  Immunogen: Peptide with sequence C-RDLQSAEKEEQEK, from the internal region of the protein sequence according to NP_005630.1.  Corresponding Immunizing Peptide:  Catalog #MBS425427
other info2 : 
Important Note: Reported isoforms NP_005630.1, NP_001129277.1 and NP_001129278.1 represent identical protein.
ncbi acc num : 
NP_005630.1
ncbi gb acc num : 
NM_005639.2
ncbi mol weight : 
47,573 Da
ncbi pathways : 
Acetylcholine Neurotransmitter Release Cycle Pathway  106525!!Disease Pathway  530764!!Dopamine Neurotransmitter Release Cycle Pathway  106523!!Effects Of Botulinum Toxin Pathway  138028!!GABA Synthesis, Release, Reuptake And Degradation Pathway  187174!!Glutamate Neurotransmitter Release Cycle Pathway  106522!!Neuronal System Pathway  106513!!Neurotoxicity Of Clostridium Toxins Pathway  105734!!Neurotransmitter Release Cycle Pathway  106518!!Norepinephrine Neurotransmitter Release Cycle Pathway  106519
ncbi summary : 
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]