antibody

Goat anti-NDEL1 Antibody

MBS422222

0.1 mg

300 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog, cow

western blot, enzyme immunoassay

Antibody

Goat anti-NDEL1 Antibody

NDEL1

NDEL1; nudE nuclear distribution gene E homolog (A. nidulans)-like 1; DKFZp451M0318; EOPA; MITAP1; NUDEL; NUDE-like protein; endooligopeptidase A; mitosin-associated protein MITAP1; nudE nuclear distribution gene E homolog like 1; NDEL1 antibody; nudE nuclear distribution gene E homolog (A. nidulans)-like 1 antibody; DKFZp451M0318 antibody; EOPA antibody; MITAP1 antibody; NUDEL antibody; NUDE-like protein antibody; endooligopeptidase A antibody; mitosin-associated protein MITAP1 antibody; nudE nuclear distribution gene E homolog like 1 antibody

nuclear distribution protein nudE-like 1 isoform A; Nuclear distribution protein nudE-like 1; nuclear distribution protein nudE-like 1; nudE neurodevelopment protein 1 like 1; Mitosin-associated protein 1

NDEL1

NDEL1; NDEL1; EOPA; NDE2; NUDEL; MITAP1; NDE1L1; EOPA; MITAP1; NUDEL; Protein Nudel

NDEL1_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

328

CRNFAKDQASRKSY

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Approx 38+39kDa bands observed in Human Brain (Cerebellum) lysates (calculated MW of 37. 0kDa according to NP_001020750.1 and of 38.4kDa according to NP_110435.1). Recommended concentration: 0.1-0.3ug/ml.

Immunogen: Peptide with sequence CRNFAKDQASRKSY, from the internal region of the protein sequence according to NP_001020750.1; NP_110435.1. Epitope: Internal region

Note: This antibody is expected to recognize both reported isoforms (NP_001020750.1; NP_110435.1).

71284108

NP_001020750.1

NM_001025579.2

37,039 Da

Aurora A Signaling Pathway (137925); Cell Cycle Pathway (1269741); Cell Cycle, Mitotic Pathway (1269763); Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway (137984); M Phase Pathway (1269810); Mitotic Anaphase Pathway (1269825); Mitotic Metaphase And Anaphase Pathway (1269823); Mitotic Prometaphase Pathway (1269820); RHO GTPase Effectors Pathway (1269509); RHO GTPases Activate Formins Pathway (1269519)

This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012]

NDEL1: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Belongs to the nudE family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Microtubule-binding; Protease. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: axon hillock; centrosome; cytosol; kinesin complex; kinetochore; leading edge; microtubule; neurofilament cytoskeleton; nuclear envelope; spindle; synaptic vesicle. Molecular Function: alpha-tubulin binding; beta-tubulin binding; microtubule binding; protein binding. Biological Process: cell migration; central nervous system neuron axonogenesis; centrosome localization; cerebral cortex radially oriented cell migration; chromosome segregation; establishment of chromosome localization; establishment of mitotic spindle orientation; inner cell mass cell proliferation; microtubule nucleation; mitotic centrosome separation; neurofilament cytoskeleton organization and biogenesis; neuron migration; nuclear envelope disassembly; positive regulation of axon extension; positive regulation of axon regeneration; positive regulation of GTPase activity; proteolysis; regulation of intracellular protein transport; retrograde axon cargo transport; sister chromatid cohesion; vesicle transport along microtubule

0.1 mg

300 USD