catalog number :
MBS422206
products full name :
Goat anti-GABRB3 Antibody
products short name :
GABRB3
products name syn :
GABRB3; gamma-aminobutyric acid (GABA) A receptor; beta 3; MGC9051; GABA(A) receptor beta-3 subunit; GABA-A receptor beta-3 subunit; GABA-alpha receptor beta-2 subunit; GABAA receptor beta-3 subunit; GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3; MGC9051; GABA(A) receptor beta-3 subunit; GABA-A receptor beta-3 subunit; GABA-alpha receptor beta-2 subunit; GABAA receptor beta-3 subunit
other names :
gamma-aminobutyric acid receptor subunit beta-3 isoform 1; Gamma-aminobutyric acid receptor subunit beta-3; gamma-aminobutyric acid receptor subunit beta-3; GABAA receptor beta-3 subunit; GABA-alpha receptor beta-2 subunit; gamma-aminobutyric acid A receptor beta 3; gamma-aminobutyric acid (GABA) A receptor, beta 3; GABA(A) receptor subunit beta-3
products gene name :
GABRB3
other gene names :
GABRB3; GABRB3; ECA5
uniprot entry name :
GBRB3_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
app notes :
Immunohistochemistry: In paraffin embedded Human Cortex shows patchy staining near or at the neuronal cell membrane. Recommended concentration, 2-4ug/ml. Western Blot: Preliminary experiments in Human Brain (Cerebral Cortex, Frontal Cortex and Cerebellum) lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml). Peptide ELISA: antibody detection limit dilution 1:8000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-EKTAKAKNDRSK, from the internal region of the protein sequence according to NP_000805.1; NP_068712.1. Corresponding Immunizing Peptide: Catalog #MBS426970
other info2 :
Important Note: This antibody is expected to recognize both reported isoforms (NP_000805.1, NP_068712.1).
ncbi acc num :
NP_000805.1
ncbi gb acc num :
NM_000814.5
ncbi mol weight :
45,006 Da
ncbi pathways :
BDNF Signaling Pathway 712093!!GABA A Receptor Activation Pathway 187179!!GABA Receptor Activation Pathway 187178!!GABAergic Synapse Pathway 377263!!GABAergic Synapse Pathway 377129!!Ion Channel Transport Pathway 187193!!Ligand-gated Ion Channel Transport Pathway 187195!!Morphine Addiction Pathway 552665!!Morphine Addiction Pathway 554808!!Neuroactive Ligand-receptor Interaction Pathway 83053
ncbi summary :
This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]