Goat anti-FTL Antibody | MyBioSource MBS422205 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-FTL Antibody

catalog :

MBS422205

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS422205

products type :

Antibody

products full name :

Goat anti-FTL Antibody

products short name :

FTL

products name syn :

Goat Anti-FTL, Biotinylated Antibody; FTL; ferritin, light polypeptide; MGC71996; L apoferritin; ferritin L subunit; ferritin L-chain; ferritin light chain; ferritin light polypeptide-like 3; FTL antibody; ferritin; light polypeptide antibody; MGC71996 antibody; L apoferritin antibody; ferritin L subunit antibody; ferritin L-chain antibody; ferritin light chain antibody; ferritin light polypeptide-like 3 antibody

other names :

ferritin light chain; Ferritin light chain; ferritin light chain; ferritin, light polypeptide

products gene name :

FTL

other gene names :

FTL; FTL; LFTD; NBIA3; Ferritin L subunit

uniprot entry name :

FRIL_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

sequence length :

175

sequence :

GEYLFERLTLKHD

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 128000. Immunohistochemistry: In paraffin embedded Human Brain Cortex shows cytoplasm staining of pyramydal neurons. Data obtained from a previous batch (different goat). Recommended concentration, 3-6ug/ml. Western Blot: Approx.20kDa band observed in Human Brain (Cerebellum), Liver and Placenta lysates and approx.22kDa band obseerved in Mouse and Rat Brain lysates (calculated MW of 20. 0kDa according to NP_000137.2). Recommended concentration: 0.1-0.3ug/ml. Enzyme immunoassay: Sandwich-type ELISA with increasing amount of recombinant FTL captured by a rabbit antibody. Data obtained from previous batch (different goat). Recommended reporter concentration: 1-2ug/ml.

other info1 :

Immunogen: Peptide with sequence C-GEYLFERLTLKHD, from the C Terminus of the protein sequence according to NP_000137.2. Epitope: C Terminus

ncbi gi num :

20149498

ncbi acc num :

NP_000137.2

ncbi gb acc num :

NM_000146.3

ncbi mol weight :

20,020 Da

ncbi pathways :

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (1269897); Clathrin Derived Vesicle Budding Pathway (1269881); Golgi Associated Vesicle Biogenesis Pathway (1269882); Integrated Pancreatic Cancer Pathway (711360); Iron Uptake And Transport Pathway (1269948); Membrane Trafficking Pathway (1269877); Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); Scavenging By Class A Receptors Pathway (1269899); Transmembrane Transport Of Small Molecules Pathway (1269903)

ncbi summary :

This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

uniprot summary :

FTL: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS). It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene. Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3); also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels. Belongs to the ferritin family. Protein type: Oxidoreductase. Chromosomal Location of Human Ortholog: 19q13.33. Cellular Component: cytosol; ferritin complex; membrane. Molecular Function: ferric iron binding; identical protein binding; iron ion binding; protein binding. Biological Process: cellular iron ion homeostasis; iron ion homeostasis; iron ion transport. Disease: Hyperferritinemia With Or Without Cataract; L-ferritin Deficiency; Neurodegeneration With Brain Iron Accumulation 3

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage