Goat anti-DLX5 Antibody | MyBioSource MBS422203 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-DLX5 Antibody

catalog :

MBS422203

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS422203

products type :

Antibody

products full name :

Goat anti-DLX5 Antibody

products short name :

DLX5

products name syn :

DLX5; distal-less homeobox 5; distal-less homeo box 5; DLX5 antibody; distal-less homeobox 5 antibody; distal-less homeo box 5 antibody

other names :

homeobox protein DLX-5; Homeobox protein DLX-5; homeobox protein DLX-5; distal-less homeobox 5

products gene name :

DLX5

other gene names :

DLX5; DLX5; SHFM1D

uniprot entry name :

DLX5_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Cow

sequence length :

289

sequence :

AYNRVPSATNQPEK

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 30kDa band observed in Human Bone Marrow lysates (calculated MW of 31.5kDa according to NP_005212.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Lee et al, J Biol Chem.2003 Sep 5;278(36): 34387-94; PMID: 12815054). Recommended concentration: 1-3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-AYNRVPSATNQPEK, from the internal region of the protein sequence according to NP_005212.1. Epitope: Internal region

ncbi gi num :

4885187

ncbi acc num :

NP_005212.1

ncbi gb acc num :

NM_005221.5

ncbi mol weight :

20,900 Da

ncbi pathways :

Neural Crest Differentiation Pathway (672460); Signaling Pathways Regulating Pluripotency Of Stem Cells (1026136); Signaling Pathways Regulating Pluripotency Of Stem Cells (1033502)

ncbi summary :

This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. [provided by RefSeq, Jul 2008]

uniprot summary :

DLX5: Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. Defects in DLX5 are the cause of split-hand/foot malformation type 1, with sensorineural hearing loss (SHFM1D). A disease characterized by the association of split- hand/foot malformation with deafness. Split-hand/foot malformation is a limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting. Belongs to the distal-less homeobox family. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 7q22. Cellular Component: cytoplasm; nuclear chromatin. Biological Process: anatomical structure formation; axon guidance; BMP signaling pathway; cell proliferation; embryonic limb morphogenesis; endochondral ossification; epithelial cell differentiation; inner ear morphogenesis; nervous system development; olfactory pit development; osteoblast differentiation; palate development; positive regulation of epithelial cell proliferation; positive regulation of osteoblast differentiation; positive regulation of transcription, DNA-dependent; skeletal development; transcription from RNA polymerase II promoter. Disease: Split-hand/foot Malformation 1 With Sensorineural Hearing Loss, Autosomal Recessive

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage