Goat anti-Granulin/GRN Antibody | MyBioSource MBS422188 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Granulin/GRN Antibody

catalog :

MBS422188

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS422188

products type :

Antibody

products full name :

Goat anti-Granulin/GRN Antibody

products short name :

Granulin/GRN

products name syn :

Goat Anti-Progranulin aa248-259 / Granulin-3 Antibody; GRN; granulin; GEP; GP88; PCDGF; PEPI; PGRN; PC cell-derived growth factor; acrogranin; granulin-epithelin; proepithelin; progranulin; GRN antibody; granulin antibody; GEP antibody; GP88 antibody; PCDGF antibody; PEPI antibody; PGRN antibody; PC cell-derived growth factor antibody; acrogranin antibody; granulin-epithelin antibody; proepithelin antibody; progranulin antibody; Granulin; Granulin / GRN

other names :

granulins; Granulins; granulins; granulin; Proepithelin; PEPI

products gene name :

GRN

other gene names :

GRN; GRN; GEP; GP88; PEPI; PGRN; CLN11; PCDGF; PEPI; GP88; Glycoprotein 88

uniprot entry name :

GRN_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human

sequence length :

593

sequence :

QSKCLSKENATTD

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Approx. 60kDa band observed in lysates of A549 and HeLa (calculated MW of 63.5kDa according to NP_002078.1). Recommended concentration: 1-3ug/ml.

other info1 :

Immunogen: Peptide with sequence QSKCLSKENATTD, from the internal region of the protein sequence according to NP_002078.1. Epitope: Internal region

ncbi gi num :

4504151

ncbi acc num :

NP_002078.1

ncbi gb acc num :

NM_002087.3

ncbi mol weight :

44,132 Da

ncbi pathways :

Integrated Breast Cancer Pathway (219801)

ncbi summary :

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]

uniprot summary :

GRN: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD); also known as tau- negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease. Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11). A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. Belongs to the granulin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 17q21.32. Cellular Component: cytosol; extracellular space; intracellular membrane-bound organelle. Molecular Function: cytokine activity; growth factor activity; protein binding. Biological Process: male mating behavior; response to estradiol stimulus; signal transduction; synaptic vesicle endocytosis. Disease: Ceroid Lipofuscinosis, Neuronal, 11; Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage