antibody

Goat anti-Polycystin 2/PKD2 Antibody

MBS422181

0.1 mg

300 USD

polyclonal

goat

nonconjugated

human, mouse, rat, cow

western blot, enzyme immunoassay

Antibody

Goat anti-Polycystin 2/PKD2 Antibody

Polycystin 2/PKD2

PKD2; polycystic kidney disease 2 (autosomal dominant); APKD2; MGC138466; MGC138468; PC2; PKD4; polycystin 2; polycystwin; PKD2 antibody; polycystic kidney disease 2 (autosomal dominant) antibody; APKD2 antibody; MGC138466 antibody; MGC138468 antibody; PC2 antibody; PKD4 antibody; polycystin 2 antibody; polycystwin antibody; Polycystin 2; Polycystin 2 / PKD2

polycystin-2; Polycystin-2; polycystin-2; polycystin 2, transient receptor potential cation channel; Autosomal dominant polycystic kidney disease type II protein; Polycystic kidney disease 2 protein; Polycystwin; R48321; Transient receptor potential cation channel subfamily P member 2

PKD2

PKD2; PKD2; PC2; PKD4; Pc-2; APKD2; TRPP2

PKD2_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Cow

968

ERAKLKRREVLGR

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 2000. Western Blot: Approx 100kDa band observed in lysates of cell line HeLa (calculated MW of 110kDa according to NP_000288.1). Recommended concentration: 1-3ug/ml.

Immunogen: Peptide with sequence C-ERAKLKRREVLGR, from the internal region of the protein sequence according to NP_000288.1. Epitope: Internal region

4505835

NP_000288.1

NM_000297.3

98,838 Da

Assembly Of The Primary Cilium Pathway (1268846); Cargo Trafficking To The Periciliary Membrane Pathway (1268848); Organelle Biogenesis And Maintenance Pathway (1268838); VxPx Cargo-targeting To Cilium Pathway (1268849)

This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]

PKD2: Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Functions as a calcium permeable cation channel. Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2). ADPKD2 is a disorder characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. It represents approximately 15% of the cases of autosomal dominant polycystic kidney disease. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy. Belongs to the polycystin family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Channel, cation; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 4q22.1. Cellular Component: basal cortex; basal plasma membrane; cilium; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; filamentous actin; integral to plasma membrane; intercellular junction; lamellipodium; motile primary cilium; nonmotile primary cilium; plasma membrane. Molecular Function: actinin binding; ATPase binding; calcium ion binding; calcium-induced calcium release activity; cytoskeletal protein binding; HLH domain binding; identical protein binding; muscle alpha-actinin binding; phosphoprotein binding; potassium channel activity; protein binding; protein homodimerization activity; receptor binding; voltage-gated calcium channel activity; voltage-gated cation channel activity; voltage-gated ion channel activity; voltage-gated sodium channel activity. Biological Process: calcium ion transport; cell cycle arrest; centrosome duplication; cytoplasmic sequestering of transcription factor; detection of mechanical stimulus; determination of left/right symmetry; embryonic placenta development; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; heart development; heart looping; JAK-STAT cascade; liver development; negative regulation of cell proliferation; neural tube development; positive regulation of inositol-1,4,5-triphosphate receptor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; regulation of cAMP metabolic process; regulation of cell proliferation; regulation of postsynaptic membrane potential; release of sequestered calcium ion into cytosol; spinal cord development; ureteric bud branching. Disease: Polycystic Kidney Disease 2

0.1 mg

300 USD