product summary
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company name :
MyBioSource
product type :
antibody
product name :
Goat anti-ATG4D Antibody
catalog :
MBS422173
quantity :
0.1 mg
price :
225 USD
clonality :
polyclonal
host :
goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dog
application :
ELISA, enzyme immunoassay
more info or order :
product information
catalog number :
MBS422173
products type :
Antibody
products full name :
Goat anti-ATG4D Antibody
products short name :
ATG4D
products name syn :
ATG4D; ATG4 autophagy related 4 homolog D (S. cerevisiae); APG4-D; APG4D; AUTL4; APG4 autophagy 4 homolog D; AUT-like 4, cysteine endopeptidase; autophagin-4; autophagy-related cysteine endopeptidase 4; cysteine protease involved in autophagy; ATG4D antibody; ATG4 autophagy related 4 homolog D (S. cerevisiae) antibody; APG4-D antibody; APG4D antibody; AUTL4 antibody; APG4 autophagy 4 homolog D antibody; AUT-like 4; cysteine endopeptidase antibody; autophagin-4 antibody; autophagy-related cysteine endopeptidase 4 antibody; cysteine protease involved in autophagy antibody
other names :
cysteine protease ATG4D isoform 1; Cysteine protease ATG4D; cysteine protease ATG4D; autophagy related 4D cysteine peptidase; AUT-like 4 cysteine endopeptidase; Autophagin-4; Autophagy-related cysteine endopeptidase 4; Autophagy-related protein 4 homolog D
products gene name :
ATG4D
other gene names :
ATG4D; ATG4D; APG4D; AUTL4; APG4-D; APG4D; AUTL4
uniprot entry name :
ATG4D_HUMAN
clonality :
Polyclonal
host :
Goat
reactivity :
Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig
sequence length :
474
sequence :
CSQLAQPTLRLPRT
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Preliminary experiments gave an approx.26kDa band in Human Skeletal Muscle lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 52.9kDa according to NP_116274.3. The 26kDa band was successfully blocked by incubation with the immunizing peptide.
other info1 :
Immunogen: Peptide with sequence CSQLAQPTLRLPRT, from the internal region (near C terminus) of the protein sequence according to NP_116274.3. Epitope: Internal region (near C Terminus)
ncbi gi num :
27903825
ncbi acc num :
NP_116274.3
ncbi gb acc num :
NM_032885.5
ncbi mol weight :
16,008 Da
ncbi pathways :
Cellular Responses To Stress Pathway (1270414); Macroautophagy Pathway (1270432); Regulation Of Autophagy Pathway (83058); Regulation Of Autophagy Pathway (468)
ncbi summary :
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
uniprot summary :
ATG4D: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Belongs to the peptidase C54 family. Protein type: Autophagy; EC 3.4.22.-; Protease; Ubiquitin conjugating system. Chromosomal Location of Human Ortholog: 19p13.2. Cellular Component: cytoplasm; cytosol; mitochondrial matrix. Molecular Function: cysteine-type endopeptidase activity. Biological Process: apoptosis; autophagic vacuole formation; C-terminal protein lipidation; mitochondrion degradation; protein delipidation; protein processing; protein targeting to membrane
size1 :
0.1 mg
price1 :
225 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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