antibody

Goat anti-LIGHT / CD258 Antibody

MBS422151

0.1 mg

290 USD

polyclonal

goat

nonconjugated

western blot, enzyme immunoassay

Antibody

Goat anti-LIGHT / CD258 Antibody

LIGHT/CD258

TNFSF14; tumor necrosis factor (ligand) superfamily; member 14; CD258; HVEML; LIGHT; LTg; TR2; delta transmembrane LIGHT; herpesvirus entry mediator A; ligand for herpesvirus entry mediator; tumor necrosis factor ligand superfamily; member 14; tumor necrosis factor receptor-like 2; tumor necrosis factor superfamily member LIGHT; TNFSF14; tumor necrosis factor (ligand) superfamily, member 14; CD258; HVEML; LIGHT; LTg; TR2; delta transmembrane LIGHT; herpesvirus entry mediator A; ligand for herpesvirus entry mediator; tumor necrosis factor ligand superfamily, member 14; tumor necrosis factor receptor-like 2; tumor necrosis factor superfamily member LIGHT

tumor necrosis factor ligand superfamily member 14 isoform 1; Tumor necrosis factor ligand superfamily member 14; tumor necrosis factor ligand superfamily member 14; delta transmembrane LIGHT; herpesvirus entry mediator A; herpesvirus entry mediator ligand; herpesvirus entry mediator-ligand; herpes virus entry mediator ligand; ligand for herpesvirus entry mediator; tumor necrosis factor receptor-like 2; tumor necrosis factor superfamily member LIGHT; tumor necrosis factor (ligand) superfamily, member 14; Herpes virus entry mediator ligand; HVEM-L; Herpesvirus entry mediator ligand; CD_antigen: CD258Cleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form

TNFSF14

TNFSF14; TNFSF14; LTg; TR2; CD258; HVEML; LIGHT; HVEML; LIGHT; HVEM-L; Herpesvirus entry mediator ligand

TNF14_HUMAN

Polyclonal

Goat

Human

240

HEVNPAAHLTGANS

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Western Blot: Approx 22kDa band observed in Human Brain (Cerebellum and Frontal Cortex) lysates (calculated MW of 22.4kDa according to NP_742011.1). Recommended concentration: 1-3ug/ml. Peptide ELISA: antibody detection limit dilution 1:64000.

Epitope: Internal Region. Immunogen: Peptide with sequence C-HEVNPAAHLTGANS, from the internal region of the protein sequence according to NP_003798.2; NP_742011.1. Corresponding Immunizing Peptide: Catalog #MBS426153

Important Note: This antibody is expected to recognize both reported isoforms (NP_003798.2; NP_742011.1).

25952144

NP_003798.2

NM_003807.3

22,395 Da

Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Herpes Simplex Infection Pathway 377873!!Herpes Simplex Infection Pathway 377865!!NF-kappa B Signaling Pathway 634527

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

0.1 mg

290 USD