catalog number :
MBS422136
products full name :
Goat anti-MAP3K6 Antibody
products short name :
MAP3K6
products name syn :
MAP3K6; mitogen-activated protein kinase kinase kinase 6; ASK2; MAPKKK6; MGC125653; MGC20114; OTTHUMP00000005063; apoptosis signal-regulating kinase 2; MAP3K6 antibody; mitogen-activated protein kinase kinase kinase 6 antibody; ASK2 antibody; MAPKKK6 antibody; MGC125653 antibody; MGC20114 antibody; OTTHUMP00000005063 antibody; apoptosis signal-regulating kinase 2 antibody
other names :
mitogen-activated protein kinase kinase kinase 6 isoform 1; Mitogen-activated protein kinase kinase kinase 6; mitogen-activated protein kinase kinase kinase 6; mitogen-activated protein kinase kinase kinase 6; Apoptosis signal-regulating kinase 2
products gene name :
MAP3K6
other gene names :
MAP3K6; MAP3K6; ASK2; MEKK6; MAPKKK6; ASK2; MAPKKK6; MEKK6
uniprot entry name :
M3K6_HUMAN
reactivity :
Tested: Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 8000.
other info1 :
Immunogen: Peptide with sequence C-RAILAQRAGSTP, from the C Terminus of the protein sequence according to NP_004663.3. Epitope: C Terminus
ncbi acc num :
NP_004663.3
ncbi gb acc num :
NM_004672.4
ncbi mol weight :
141,648 Da
ncbi pathways :
Insulin Signaling Pathway (198845); MAPK (JNK) Signaling Pathway (1084764); MAPK (JNK) Signaling Pathway (1108227); MAPK (p38) Signaling Pathway (1084765); MAPK (p38) Signaling Pathway (1108228); MAPK Signaling Pathway (198779); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); P38 MAPK Signaling Pathway (137943)
ncbi summary :
This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
uniprot summary :
MEKK6: a member of the STE11 protein kinase family. Activates JNK, but not ERK or p38. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Protein type: EC 2.7.11.25; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family. Chromosomal Location of Human Ortholog: 1p36.11. Cellular Component: intracellular. Molecular Function: ATP binding; magnesium ion binding; MAP kinase kinase kinase activity. Biological Process: activation of JNK activity; activation of MAPKK activity; protein amino acid phosphorylation; signal transduction