product summary
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company name :
MyBioSource
product type :
antibody
product name :
Goat anti-LASS5+6/CerS5+6 Antibody
catalog :
MBS422118
quantity :
0.1 mg
price :
225 USD
clonality :
polyclonal
host :
goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dog, cow
application :
ELISA, enzyme immunoassay
more info or order :
product information
catalog number :
MBS422118
products type :
Antibody
products full name :
Goat anti-LASS5+6/CerS5+6 Antibody
products short name :
LASS5+6/CerS5+6
products name syn :
LASS5; LAG1 homolog, ceramide synthase 5; CerS5; FLJ25304; MGC45411; Trh4; LAG1 longevity assurance homolog 5; LASS5 antibody; LAG1 homolog; ceramide synthase 5 antibody; CerS5 antibody; FLJ25304 antibody; MGC45411 antibody; Trh4 antibody; LAG1 longevity assurance homolog 5 antibody; LASS5+6 / CerS5+6
other names :
ceramide synthase 5 isoform 1; Ceramide synthase 5; ceramide synthase 5; ceramide synthase 5; LAG1 longevity assurance homolog 5
products gene name :
LASS5
products gene name syn :
LASS5+6; CerS5+6
other gene names :
CERS5; CERS5; Trh4; LASS5; LASS5; CerS5
uniprot entry name :
CERS5_HUMAN
clonality :
Polyclonal
host :
Goat
reactivity :
Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
sequence length :
392
sequence :
RGKVSKDDRSDVES
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 4000. Western Blot: Preliminary experiments gave an approx. 60kDa band in lysates of HEK293, HeLa and HepG2 after 0.5ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 45.8kDa according to NP_671723.1. The 60kDa band was successfully blocked by incubation with the immunizing peptide.
other info1 :
Immunogen: Peptide with sequence C-RGKVSKDDRSDVES, from the internal region of the protein sequence according to NP_671723.1; NP_982288.1. Epitope: Internal region
other info2 :
Note: This antibbody is expected to cross-react with the highly similar LASS6.
ncbi gi num :
22218345
ncbi acc num :
NP_671723.1
ncbi gb acc num :
NM_147190.3
ncbi mol weight :
39,259 Da
ncbi pathways :
Ceramide Biosynthesis Pathway (524496); Ceramide Biosynthesis Pathway (468287); Metabolic Pathways (132956); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Sphingolipid Metabolism Pathway (760636); Sphingolipid De Novo Biosynthesis Pathway (1270098); Sphingolipid Metabolism Pathway (82994); Sphingolipid Metabolism Pathway (1270097); Sphingolipid Metabolism Pathway (369)
ncbi summary :
This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
uniprot summary :
LASS5: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl- (C16) ceramide) in a fumonisin B1-independent manner. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transferase; EC 2.3.1.24; DNA-binding. Chromosomal Location of Human Ortholog: 12q13.12. Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nuclear membrane. Molecular Function: DNA binding; sphingosine N-acyltransferase activity. Biological Process: ceramide biosynthetic process; sphingolipid biosynthetic process
size1 :
0.1 mg
price1 :
225 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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