Goat anti-KCNN2 Antibody | MyBioSource MBS422106 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-KCNN2 Antibody

catalog :

MBS422106

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, dog

application :

western blot, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS422106

products type :

Antibody

products full name :

Goat anti-KCNN2 Antibody

products short name :

KCNN2

products name syn :

KCNN2; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; KCa2.2; SK2; SKCA2; hSK2; apamin-sensitive small-conductance Ca2+-activated potassium channel; small conductance calcium-activated potassium channel protein; KCNN2 antibody; potassium intermediate/small conductance calcium-activated channel; subfamily N; member 2 antibody; KCa2.2 antibody; SK2 antibody; SKCA2 antibody; hSK2 antibody; apamin-sensitive small-conductance Ca2+-activated potassium channel antibody; small conductance calcium-activated potassium channel protein 2 antibody

other names :

small conductance calcium-activated potassium channel protein 2 isoform a; Small conductance calcium-activated potassium channel protein 2; small conductance calcium-activated potassium channel protein 2; potassium calcium-activated channel subfamily N member 2; KCa2.2

products gene name :

KCNN2

other gene names :

KCNN2; KCNN2; SK2; hSK2; SKCA2; KCa2.2; SKCa 2; SK2; SKCa 2; SKCa2

uniprot entry name :

KCNN2_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

sequence length :

579

sequence :

ESYDKHVTYNAER

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 64000. Immunohistochemistry: In paraffin embedded Humam Thyroid Gland shows membranous staining in the epithelial cells. Recommended concentration, 1-2ug/ml. Western Blot: Approx 70kDa and 23kDa bands observed in Human Liver lysates (calculated MW of 63.8kDa according to NP_067627.2 and of 26.3kDa according to NP_740721.1). Recommended concentration: 0.3-1ug/ml.

other info1 :

Immunogen: Peptide with sequence C-ESYDKHVTYNAER, from the internal region of the protein sequence according to NP_067627.2; NP_740721.1. Epitope: Internal region

other info2 :

Note: This antibody is expected to recognize both isoforms (NP_067627.2; NP_740721.1).

ncbi gi num :

25777645

ncbi acc num :

NP_067627.2

ncbi gb acc num :

NM_021614.3

ncbi mol weight :

26,341 Da

ncbi pathways :

BDNF Signaling Pathway (712093); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Ca2+ Activated K+ Channels Pathway (1268822); Insulin Secretion Pathway (777534); Neuronal System Pathway (1268763); Potassium Channels Pathway (1268821); Serotonergic Synapse Pathway (525336)

ncbi summary :

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

uniprot summary :

KCNN2: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily. Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 5q22.3. Cellular Component: cell soma; cell surface; dendritic spine; integral to membrane; plasma membrane; smooth endoplasmic reticulum; T-tubule; Z disc. Molecular Function: alpha-actinin binding; calcium-activated potassium channel activity; calmodulin binding; protein domain specific binding; protein homodimerization activity; small conductance calcium-activated potassium channel activity. Biological Process: potassium ion transport

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage